Literature DB >> 1375459

Effect of NADPH oxidase inhibition on endothelial cell ELAM-1 mRNA expression.

Y Suzuki1, W Wang, T H Vu, T A Raffin.   

Abstract

Neutrophil adherence to endothelium is partially mediated by the expression of endothelial leukocyte adhesion molecule-1 (ELAM-1) on endothelial cells activated by agents such as lipopolysaccharide (LPS) and phorbol myristate acetate (PMA). To elucidate molecular mechanisms involved in the induction of ELAM-1 on endothelial cells, we investigated the effect of the NADPH oxidase inhibitor, apocynin (4-hydroxy-3-methoxyacetophenone), on ELAM-1 mRNA expression in human umbilical vein endothelial cells (HUVEC) by Northern blot analysis. Apocynin downregulated both LPS- and PMA-induced ELAM-1 mRNA expression in a dose-dependent manner. Our results suggest NADPH oxidase might play a key role in ELAM-1 mRNA expression in HUVEC.

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Year:  1992        PMID： 1375459     DOI： 10.1016/s0006-291x(05)80029-4

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  9 in total

1.  Angiotensin II evokes sensory long-term facilitation of the carotid body via NADPH oxidase.

Authors:  Ying-Jie Peng; Gayatri Raghuraman; Shakil A Khan; Ganesh K Kumar; Nanduri R Prabhakar
Journal:  J Appl Physiol (1985)       Date:  2011-06-02

2.  5-HT evokes sensory long-term facilitation of rodent carotid body via activation of NADPH oxidase.

Authors:  Ying-Jie Peng; Guoxiang Yuan; Frank J Jacono; Ganesh K Kumar; Nanduri R Prabhakar
Journal:  J Physiol       Date:  2006-08-03       Impact factor: 5.182

3.  Molecular imaging of inflammation and platelet adhesion in advanced atherosclerosis effects of antioxidant therapy with NADPH oxidase inhibition.

Authors:  Yani Liu; Brian P Davidson; Qi Yue; Todd Belcik; Aris Xie; Yoichi Inaba; Owen J T McCarty; Garth W Tormoen; Yan Zhao; Zaverio M Ruggeri; Beat A Kaufmann; Jonathan R Lindner
Journal:  Circ Cardiovasc Imaging       Date:  2012-12-13       Impact factor: 7.792

4.  Molecular imaging reveals rapid reduction of endothelial activation in early atherosclerosis with apocynin independent of antioxidative properties.

Authors:  Elham Khanicheh; Yue Qi; Aris Xie; Martina Mitterhuber; Lifen Xu; Michika Mochizuki; Youssef Daali; Vincent Jaquet; Karl-Heinz Krause; Zaverio M Ruggeri; Gabriela M Kuster; Jonathan R Lindner; Beat A Kaufmann
Journal:  Arterioscler Thromb Vasc Biol       Date:  2013-08-01       Impact factor: 8.311

Review 5.  The role of endothelial mechanosensitive genes in atherosclerosis and omics approaches.

Authors:  Rachel D Simmons; Sandeep Kumar; Hanjoong Jo
Journal:  Arch Biochem Biophys       Date:  2015-12-11       Impact factor: 4.013

Review 6.  NADPH oxidase(s): new source(s) of reactive oxygen species in the vascular system?

Authors:  L Van Heerebeek; C Meischl; W Stooker; C J L M Meijer; H W M Niessen; D Roos
Journal:  J Clin Pathol       Date:  2002-08       Impact factor: 3.411

7.  Oxygen radicals as second messengers for expression of the monocyte chemoattractant protein, JE/MCP-1, and the monocyte colony-stimulating factor, CSF-1, in response to tumor necrosis factor-alpha and immunoglobulin G. Evidence for involvement of reduced nicotinamide adenine dinucleotide phosphate (NADPH)-dependent oxidase.

Authors:  J A Satriano; M Shuldiner; K Hora; Y Xing; Z Shan; D Schlondorff
Journal:  J Clin Invest       Date:  1993-09       Impact factor: 14.808

8.  Activation and attenuation of transcription factor NF-kB in mouse glomerular mesangial cells in response to tumor necrosis factor-alpha, immunoglobulin G, and adenosine 3':5'-cyclic monophosphate. Evidence for involvement of reactive oxygen species.

Authors:  J Satriano; D Schlondorff
Journal:  J Clin Invest       Date:  1994-10       Impact factor: 14.808

Review 9.  NOX enzymes as novel targets for drug development.

Authors:  J David Lambeth; Karl-Heinz Krause; Robert A Clark
Journal:  Semin Immunopathol       Date:  2008-05-29       Impact factor: 11.759
  9 in total

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