Literature DB >> 1374584

Infiltration of helper/inducer T lymphocytes heralds central nervous system damage in human T-cell leukemia virus infection.

Y Iwasaki1, Y Ohara, I Kobayashi, S Akizuki.   

Abstract

Cellular infiltrates in new and old lesions in two cases of human T-cell leukemia virus associated myelopathy (HAM) were analyzed with anti-CD3 antibody and OPD4 antibody recognizing CD4 + CD45RO + T lymphocytes. A subset of CD4 lymphocytes with helper/inducer function and labeled with OPD4 constitutes up to 65% of CD3 cells in new lesions in the pons and the cervical cord. In contrast, nonhelper cells and macrophages were dominant in long-standing spinal cord lesions of these HAM cases and inflammatory lesions in two cases of Japanese encephalitis. Thus, unlike in viral infections, the central nervous system (CNS) tissue damage associated with human T-cell leukemia virus (HTLV-1) infection appeared to be heralded by the infiltration of helper/inducer T cells.

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Year:  1992        PMID： 1374584      PMCID： PMC1886515     

Source DB:  PubMed          Journal:  Am J Pathol        ISSN： 0002-9440            Impact factor:   4.307


  25 in total

1.  Isolation of an HTLV-1-like retrovirus from patients with tropical spastic paraparesis.

Authors:  S Jacobson; C S Raine; E S Mingioli; D E McFarlin
Journal:  Nature       Date:  1988-02-11       Impact factor: 49.962

2.  Pathological and immunological observations on tropical spastic paraparesis in patients from Jamaica.

Authors:  P Piccardo; M Ceroni; P Rodgers-Johnson; C Mora; D M Asher; G Char; C J Gibbs; D C Gajdusek
Journal:  Ann Neurol       Date:  1988       Impact factor: 10.422

3.  Necropsy findings in HTLV-I associated myelopathy.

Authors:  S Akizuki; O Nakazato; Y Higuchi; K Tanabe; M Setoguchi; S Yoshida; Y Miyazaki; S Yamamoto; S Sudou; K Sannomiya
Journal:  Lancet       Date:  1987-01-17       Impact factor: 79.321

4.  Loss of functional suppression is linked to decreases in circulating suppressor inducer (CD4+ 2H4+) T cells in multiple sclerosis.

Authors:  M Chofflon; H L Weiner; C Morimoto; D A Hafler
Journal:  Ann Neurol       Date:  1988-08       Impact factor: 10.422

5.  Two distinct antigen systems in human B lymphocytes: identification of cell surface and intracellular antigens using monoclonal antibodies.

Authors:  Y Ishii; T Takami; H Yuasa; T Takei; K Kikuchi
Journal:  Clin Exp Immunol       Date:  1984-10       Impact factor: 4.330

6.  Analysis of factors of relevance to rapid clinical progression in HTLV-I-associated myelopathy.

Authors:  Y Kuroda; F Fujiyama; F Nagumo
Journal:  J Neurol Sci       Date:  1991-09       Impact factor: 3.181

7.  Multiple sclerosis. Distribution of T cells, T cell subsets and Ia-positive macrophages in lesions of different ages.

Authors:  U Traugott; E L Reinherz; C S Raine
Journal:  J Neuroimmunol       Date:  1983-06       Impact factor: 3.478

8.  Tropical spastic paraparesis and human T cell lymphotropic virus type 1 in the United Kingdom.

Authors:  J K Cruickshank; P Rudge; A G Dalgleish; M Newton; B N McLean; R O Barnard; B E Kendall; D H Miller
Journal:  Brain       Date:  1989-08       Impact factor: 13.501

9.  Leukoencephalopathy in HTLV-I-associated myelopathy: MRI and EEG data.

Authors:  J Kira; S Minato; Y Itoyama; I Goto; M Kato; K Hasuo
Journal:  J Neurol Sci       Date:  1988-11       Impact factor: 3.181

10.  Increases in helper inducer T cells and activated T cells in HTLV-I-associated myelopathy.

Authors:  Y Itoyama; J Kira; N Fujii; I Goto; N Yamamoto
Journal:  Ann Neurol       Date:  1989-08       Impact factor: 10.422
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  23 in total

1.  HLA alleles determine human T-lymphotropic virus-I (HTLV-I) proviral load and the risk of HTLV-I-associated myelopathy.

Authors:  K J Jeffery; K Usuku; S E Hall; W Matsumoto; G P Taylor; J Procter; M Bunce; G S Ogg; K I Welsh; J N Weber; A L Lloyd; M A Nowak; M Nagai; D Kodama; S Izumo; M Osame; C R Bangham
Journal:  Proc Natl Acad Sci U S A       Date:  1999-03-30       Impact factor: 11.205

Review 2.  Mechanisms of T-cell activation by human T-cell lymphotropic virus type I.

Authors:  P Höllsberg
Journal:  Microbiol Mol Biol Rev       Date:  1999-06       Impact factor: 11.056

3.  Do T cells cause HTLV-1-associated disease?: a taxing problem.

Authors:  S Daenke; C R Bangham
Journal:  Clin Exp Immunol       Date:  1994-05       Impact factor: 4.330

4.  Phenotypes of mononuclear cell infiltrates in human central nervous system.

Authors:  Y Iwasaki; K Sako; I Tsunoda; Y Ohara
Journal:  Acta Neuropathol       Date:  1993       Impact factor: 17.088

Review 5.  Pathogenesis and treatment of HTLV-I associated myelopathy.

Authors:  G P Taylor
Journal:  Sex Transm Infect       Date:  1998-10       Impact factor: 3.519

Review 6.  Human T-lymphotropic virus type 1 (HTLV-1): persistence and immune control.

Authors:  Charles R M Bangham
Journal:  Int J Hematol       Date:  2003-11       Impact factor: 2.490

7.  Increased number of circulating HTLV-1 infected cells in peripheral blood mononuclear cells of HTLV-1 uveitis patients: a quantitative polymerase chain reaction study.

Authors:  A Ono; M Mochizuki; K Yamaguchi; N Miyata; T Watanabe
Journal:  Br J Ophthalmol       Date:  1995-03       Impact factor: 4.638

8.  Subacute panencephalitis associated with chronic graft-versus-host disease.

Authors:  Y Iwasaki; K Sako; Y Ohara; M Miyazawa; M Minegishi; S Tsuchiya; T Konno
Journal:  Acta Neuropathol       Date:  1993       Impact factor: 17.088

9.  High circulating frequencies of tumor necrosis factor alpha- and interleukin-2-secreting human T-lymphotropic virus type 1 (HTLV-1)-specific CD4+ T cells in patients with HTLV-1-associated neurological disease.

Authors:  Peter K C Goon; Tadahiko Igakura; Emmanuel Hanon; Angelina J Mosley; Becca Asquith; Keith G Gould; Graham P Taylor; Jonathan N Weber; Charles R M Bangham
Journal:  J Virol       Date:  2003-09       Impact factor: 5.103

10.  Neuroaxonal dystrophy in HTLV-1-associated myelopathy/tropical spastic paraparesis: neuropathologic and neuroimmunologic correlations.

Authors:  E Wu; D W Dickson; S Jacobson; C S Raine
Journal:  Acta Neuropathol       Date:  1993       Impact factor: 17.088
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