Literature DB >> 1374373

KS-505a, a novel inhibitor of bovine brain Ca2+ and calmodulin-dependent cyclic-nucleotide phosphodiesterase from Streptomyces argenteolus.

S Nakanishi1, K Osawa, Y Saito, I Kawamoto, K Kuroda, H Kase.   

Abstract

A novel compound, KS-505a was isolated from the culture broth of a strain identified as Streptomyces argenteolus A-2. The compound inhibited bovine brain Ca2+ and calmodulin-dependent cyclic-nucleotide phosphodiesterase with an IC50 value (the concentration causing 50% inhibition) of 0.065 microM. The compound around that concentration had little or no effect on heart calmodulin-dependent and -independent cyclic-nucleotide phosphodiesterases, and protein kinase C.

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Year:  1992        PMID： 1374373     DOI： 10.7164/antibiotics.45.341

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  4 in total

1.  Biosynthesis of a natural polyketide-isoprenoid hybrid compound, furaquinocin A: identification and heterologous expression of the gene cluster.

Authors:  Takashi Kawasaki; Yutaka Hayashi; Tomohisa Kuzuyama; Kazuo Furihata; Nobuya Itoh; Haruo Seto; Tohru Dairi
Journal:  J Bacteriol       Date:  2006-02       Impact factor: 3.490

2.  KS-505a, an isoform-selective inhibitor of calmodulin-dependent cyclic nucleotide phosphodiesterase.

Authors:  M Ichimura; R Eiki; K Osawa; S Nakanishi; H Kase
Journal:  Biochem J       Date:  1996-05-15       Impact factor: 3.857

3.  A polycyclic terpenoid that alleviates oxidative stress.

Authors:  T Bosak; R M Losick; A Pearson
Journal:  Proc Natl Acad Sci U S A       Date:  2008-04-24       Impact factor: 11.205

Review 4.  Bacterial terpenome.

Authors:  Jeffrey D Rudolf; Tyler A Alsup; Baofu Xu; Zining Li
Journal:  Nat Prod Rep       Date:  2021-05-26       Impact factor: 15.111
  4 in total

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