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Literature DB >> 1373391

An interferon-induced protein with release factor activity is a tryptophanyl-tRNA synthetase.

F C Bange¹, T Flohr, U Buwitt, E C Böttger.

Abstract

Interferon gamma induces expression of a protein termed IFP 53 according to its molecular weight of 53 kDa. IFP 53 shows significant sequence homology to rabbit peptide chain release factor as well as to bovine tryptophanyl-tRNA synthetase. IFP 53 has been shown to possess release factor activity for the UGA stop codon. We demonstrate here, by using a recombinant IFP 53 fusion protein, that IFP 53 tryptophanylates tRNA. These data indicate that IFP 53 is a protein with two activities: peptide chain termination and aminoacylation.

Entities: Gene Species

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Year: 1992 PMID： 1373391 DOI： 10.1016/0014-5793(92)80187-l

Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124

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Cited

11 in total

1. Trp-tRNA synthetase bridges DNA-PKcs to PARP-1 to link IFN-γ and p53 signaling.

Authors: Mathew Sajish; Quansheng Zhou; Shuji Kishi; Delgado M Valdez; Mili Kapoor; Min Guo; Sunhee Lee; Sunghoon Kim; Xiang-Lei Yang; Paul Schimmel
Journal: Nat Chem Biol Date: 2012-04-15 Impact factor: 15.040

2. Proteomic analysis of human hepatoma cells expressing methionine adenosyltransferase I/III: Characterization of DDX3X as a target of S-adenosylmethionine.

Authors: Paul C Schröder; Joaquín Fernández-Irigoyen; Emilie Bigaud; Antonio Serna; Rubén Renández-Alcoceba; Shelly C Lu; José M Mato; Jesús Prieto; Fernando J Corrales
Journal: J Proteomics Date: 2012-01-16 Impact factor: 4.044

3. WRS-85D: A tryptophanyl-tRNA synthetase expressed to high levels in the developing Drosophila salivary gland.

Authors: P Seshaiah; D J Andrew
Journal: Mol Biol Cell Date: 1999-05 Impact factor: 4.138

4. Sequence comparison of new prokaryotic and mitochondrial members of the polypeptide chain release factor family predicts a five-domain model for release factor structure.

Authors: H J Pel; M Rep; L A Grivell
Journal: Nucleic Acids Res Date: 1992-09-11 Impact factor: 16.971

5. The yeast nuclear gene MRF1 encodes a mitochondrial peptide chain release factor and cures several mitochondrial RNA splicing defects.

Authors: H J Pel; C Maat; M Rep; L A Grivell
Journal: Nucleic Acids Res Date: 1992-12-11 Impact factor: 16.971

An interferon-induced protein with release factor activity is a tryptophanyl-tRNA synthetase.

1. Trp-tRNA synthetase bridges DNA-PKcs to PARP-1 to link IFN-γ and p53 signaling.

2. Proteomic analysis of human hepatoma cells expressing methionine adenosyltransferase I/III: Characterization of DDX3X as a target of S-adenosylmethionine.

3. WRS-85D: A tryptophanyl-tRNA synthetase expressed to high levels in the developing Drosophila salivary gland.

4. Sequence comparison of new prokaryotic and mitochondrial members of the polypeptide chain release factor family predicts a five-domain model for release factor structure.

5. The yeast nuclear gene MRF1 encodes a mitochondrial peptide chain release factor and cures several mitochondrial RNA splicing defects.

6. Depletion of tryptophan is not involved in expression of tryptophanyl-tRNA synthetase mediated by interferon.

7. A new gamma-interferon-inducible promoter and splice variants of an anti-angiogenic human tRNA synthetase.

8. The "eRF" clone corresponds to tryptophanyl-tRNA synthetase, not mammalian release factor.

9. Mammalian polypeptide chain release factor and tryptophanyl-tRNA synthetase are distinct proteins.

10. Iodine alters gene expression in the MCF7 breast cancer cell line: evidence for an anti-estrogen effect of iodine.