Literature DB >> 1398953

Depletion of tryptophan is not involved in expression of tryptophanyl-tRNA synthetase mediated by interferon.

T Flohr1, F C Bange, A von Euch, M Kiekenbeck, E C Böttger.   

Abstract

Gamma interferon (IFN-gamma) affects tryptophan metabolism by mediating the expression of indoleamine 2,3-dioxygenase and tryptophanyl-tRNA synthetase. In the present study, we investigated the role of indoleamine 2,3-dioxygenase-mediated tryptophan depletion in the induction of tryptophanyl-tRNA synthetase by IFN-gamma. The addition of excess tryptophan to the culture medium did not affect the induction of tryptophanyl-tRNA synthetase by IFN-gamma, indicating that tryptophan degradation is not directly involved in the IFN-gamma-mediated expression of tryptophanyl-tRNA synthetase.

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Year:  1992        PMID： 1398953      PMCID： PMC257482          DOI： 10.1128/iai.60.10.4418-4421.1992

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  27 in total

Review 1.  Interferons and their actions.

Authors:  S Pestka; J A Langer; K C Zoon; C E Samuel
Journal:  Annu Rev Biochem       Date:  1987       Impact factor: 23.643

2.  Induction of tryptophan catabolism is the mechanism for gamma-interferon-mediated inhibition of intracellular Chlamydia psittaci replication in T24 cells.

Authors:  G I Byrne; L K Lehmann; G J Landry
Journal:  Infect Immun       Date:  1986-08       Impact factor: 3.441

3.  Overexpression of mammalian phenylalanyl-tRNA synthetase upon phenylalanine restriction.

Authors:  M Lazard; M Mirande; J P Waller
Journal:  FEBS Lett       Date:  1987-05-25       Impact factor: 4.124

Review 4.  Regulation of the biosynthesis of aminoacid: tRNA ligases and of tRNA.

Authors:  S D Morgan; D Söll
Journal:  Prog Nucleic Acid Res Mol Biol       Date:  1978

5.  Dependence of the in vitro antiproliferative activity of recombinant human gamma-interferon on the concentration of tryptophan in culture media.

Authors:  L M de la Maza; E M Peterson
Journal:  Cancer Res       Date:  1988-01-15       Impact factor: 12.701

6.  Interferon-induced indoleamine 2,3-dioxygenase activity inhibits Chlamydia psittaci replication in human macrophages.

Authors:  J M Carlin; E C Borden; G I Byrne
Journal:  J Interferon Res       Date:  1989-06

7.  Interferon gamma blocks the growth of Toxoplasma gondii in human fibroblasts by inducing the host cells to degrade tryptophan.

Authors:  E R Pfefferkorn
Journal:  Proc Natl Acad Sci U S A       Date:  1984-02       Impact factor: 11.205

8.  Cycloheximide, an inhibitor of protein synthesis, prevents gamma-interferon-induced expression of class II mRNA in a macrophage cell line.

Authors:  E C Böttger; M A Blanar; R A Flavell
Journal:  Immunogenetics       Date:  1988       Impact factor: 2.846

9.  Induction of indoleamine 2,3-dioxygenase: a mechanism of the antitumor activity of interferon gamma.

Authors:  Y Ozaki; M P Edelstein; D S Duch
Journal:  Proc Natl Acad Sci U S A       Date:  1988-02       Impact factor: 11.205

10.  Mechanism of interferon-gamma action. Characterization of indoleamine 2,3-dioxygenase in cultured human cells induced by interferon-gamma and evaluation of the enzyme-mediated tryptophan degradation in its anticellular activity.

Authors:  O Takikawa; T Kuroiwa; F Yamazaki; R Kido
Journal:  J Biol Chem       Date:  1988-02-05       Impact factor: 5.157
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  2 in total

1.  Interleukin-1 inhibits gamma interferon-induced bacteriostasis in human uroepithelial cells.

Authors:  W Däubener; C Hucke; K Seidel; U Hadding; C R MacKenzie
Journal:  Infect Immun       Date:  1999-11       Impact factor: 3.441

2.  WRS-85D: A tryptophanyl-tRNA synthetase expressed to high levels in the developing Drosophila salivary gland.

Authors:  P Seshaiah; D J Andrew
Journal:  Mol Biol Cell       Date:  1999-05       Impact factor: 4.138
  2 in total

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