Some pharmacological actions of synthetic analogues of angiotensinamide.

In order to evaluate the importance of some structural features of asparagyl(1)-Valyl(5)-angiotensin II (angiotensinamide) for its pharmacological actions, the relative potencies of angiotensinamide and five peptide analogues were studied on the blood pressure of the rat, the isolated rat uterus and the isolated guinea-pig ileum. All the modifications of the angiotensinamide structure that were studied led to a decrease of potency which, however, was not the same on all three preparations. The importance of the guanido group, the phenolic group and the length of the peptide chain for the pharmacological activities of these peptides is discussed.