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Literature DB >> 13651590

The biological activity of a new analogue of oxytocin in which the tyrosyl group is replaced by phenylalanyl.

Abstract

A new synthetic analogue of oxytocin with a phenylalanyl group instead of a tyrosyl group has been investigated. The most prominent biological properties of this peptide were its oxytocic activity on the rat or cat uterus in vivo and on milk-ejection pressure in the rabbit. Another remarkable feature was the striking difference in pressor activity measured in spinal cats and in anaesthetized rats. The presence of the phenylalanyl group in the molecule in the above-mentioned position did not increase the antidiuretic potency in unanaesthetized rats. The authors propose a nomenclature for the peptides related to oxytocin and vasopressin.

Entities: Gene Species

Keywords: OXYTOCIN/related compounds

Mesh：

Substances：

Year: 1959 PMID： 13651590 PMCID： PMC1481832 DOI： 10.1111/j.1476-5381.1959.tb00939.x

Source DB: PubMed Journal: Br J Pharmacol Chemother ISSN： 0366-0826

9 in total

8. A method of conducting a biological assay on a preparation giving repeated graded responses illustrated by the estimation of histamine.

Authors: H O Schild
Journal: J Physiol Date: 1942-06-02 Impact factor: 5.182

9. Some pharmacological actions of four synthetic analogues of oxytocin.

Authors: B BERDE; W DOEPFNER; H KONZETT
Journal: Br J Pharmacol Chemother Date: 1957-06

9 in total

6 in total

Review 1. [MEDICAL AND BIOLOGICAL ASPECTS OF PHARMACOLOGICAL WORKS WITH SYNTHETIC PEPTIDES OF THE NEUROHYPOPHYSIAL TYPE].

Authors: B BERDE; A CERLETTI
Journal: Klin Wochenschr Date: 1964-12-01

2. The effect of oxytocin and vasopressin and of phenylalanyl 3-oxytocin on the urinary excretion of water and electrovtes.

Authors: W B THOMSON
Journal: J Physiol Date: 1960-02 Impact factor: 5.182

The biological activity of a new analogue of oxytocin in which the tyrosyl group is replaced by phenylalanyl.

1. Effect of valyl-oxytocin on the human subject.

2. [Experimental demonstration of the action of oxytocin on the mammary gland].

3. Further properties of isoglutamine-oxytocin; inhibition of pressor activity of vasopressin.

4. The cyclic disulfide ring of oxytocin.

5. Synthesis and biological activity of a new potent analogue of oxytocin.

6. [Syntocinon, a synthetic uterus-effective posterior pituitary hormone].

7. The quantitative assay of vasopressin.

8. A method of conducting a biological assay on a preparation giving repeated graded responses illustrated by the estimation of histamine.

9. Some pharmacological actions of four synthetic analogues of oxytocin.

Review 1. [MEDICAL AND BIOLOGICAL ASPECTS OF PHARMACOLOGICAL WORKS WITH SYNTHETIC PEPTIDES OF THE NEUROHYPOPHYSIAL TYPE].

2. The effect of oxytocin and vasopressin and of phenylalanyl 3-oxytocin on the urinary excretion of water and electrovtes.

3. Neurohypophysial hormones of non-mammalian vertebrates.

4. Some pharmacological actions of synthetic analogues of angiotensinamide.

5. Deamino-1-phenylalanine-2-arginine-8-vasopressin: a peptide with highly selective antidiuretic activity.

6. Effect of tyrosinase preparations on oxytocin, vasopressin and bradykinin.