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Literature DB >> 13725485

The formation of an isoprenaline-like substance from adrenaline.

Abstract

Intravenous injections of adrenaline, but not those of noradrenaline, caused the appearance of a substance which resembled isoprenaline in R(F) value and pharmacological activity in blood withdrawn from the lower abdominal aortae of chloralosed cats rested after acute adrenalectomy and induction of lasting block in autonomic ganglia with hexamethonium. The formation of the isoprenaline-like compound was prevented by pretreatment with pyrogallol but not by pretreatment with reserpine, cocaine, phentolamine, dibenamine, harmaline, or iproniazid. The liver proved a main site of the origin of this isoprenaline-like substance.

Entities: Chemical Species

Keywords: EPINEPHRINE/metabolism

Mesh：

Substances：

Year: 1961 PMID： 13725485 PMCID： PMC1482014 DOI： 10.1111/j.1476-5381.1961.tb00303.x

Source DB: PubMed Journal: Br J Pharmacol Chemother ISSN： 0366-0826

8 in total

1. [Action of pyrogallol on the quantity of noradrenalin liberated by the stimulation of the splenic nerves].

Authors: Z M BACQ; G L BROWN; C B FERRY
Journal: C R Hebd Seances Acad Sci Date: 1960-01-04

2. O-Methylation, the principal route of metabolism of epinephrine in man.

Authors: E H LABROSSE; J AXELROD; S S KETY
Journal: Science Date: 1958-09-12 Impact factor: 47.728

3. Chromatographic studies of the effect of intravenous injections of tyramine on the concentrations of adrenaline and noradrenaline in plasma.

Authors: M F LOCKETT; K E EAKINS
Journal: J Pharm Pharmacol Date: 1960-09 Impact factor: 3.765

5 in total

1. VASODILATATION IN SKELETAL MUSCLE PRODUCED BY AN APPARENT METABOLITE OF ADRENALINE.

Authors: D J ROBERTS
Journal: Br J Pharmacol Chemother Date: 1965-06

2. Forearm blood flow during prolonged intra-arterial infusions of adrenaline, and the effects of intra-arterial adrenaline on post-exercise hyperaemia.

Authors: W E GLOVER; R G SHANKS
Journal: J Physiol Date: 1963-07 Impact factor: 5.182

Review 3. Pressor agents.

Authors: N T Smith
Journal: Calif Med Date: 1967-07

4. The identification of a lipid-mobilizing factor from sheep midbrain.

Authors: P P Shah; A R Tee; P D English; B T Redman; J Bunyan
Journal: Biochem J Date: 1972-11 Impact factor: 3.857

5. Effect of dichloroisoprenaline on the peripheral vascular responses to adrenaline in man.

Authors: W E GLOVER; A D GREENFIELD; R G SHANKS
Journal: Br J Pharmacol Chemother Date: 1962-10

5 in total

The formation of an isoprenaline-like substance from adrenaline.

1. [Action of pyrogallol on the quantity of noradrenalin liberated by the stimulation of the splenic nerves].

2. O-Methylation, the principal route of metabolism of epinephrine in man.

3. Chromatographic studies of the effect of intravenous injections of tyramine on the concentrations of adrenaline and noradrenaline in plasma.

4. The mechanism of serotonin and catecholamine uptake by platelets.

5. The output of sympathetic transmitter from the spleen of the cat.

6. The release of chemical transmitter from the sympathetic nerves of the intestine of the cat.

7. Effect of reserpine vasoconstriction caused by sympathomimetic amines.

8. The estimation of adrenaline and allied substances in blood.

1. VASODILATATION IN SKELETAL MUSCLE PRODUCED BY AN APPARENT METABOLITE OF ADRENALINE.

2. Forearm blood flow during prolonged intra-arterial infusions of adrenaline, and the effects of intra-arterial adrenaline on post-exercise hyperaemia.

Review 3. Pressor agents.

4. The identification of a lipid-mobilizing factor from sheep midbrain.

5. Effect of dichloroisoprenaline on the peripheral vascular responses to adrenaline in man.