Literature DB >> 13580222

O-Methylation, the principal route of metabolism of epinephrine in man.

E H LABROSSE, J AXELROD, S S KETY.   

Abstract

Evidence is presented which indicates that the principal pathway of metabolism of epinephrine in man is O-methylation to metanephrine. The extent of the conLversion to metanephrine, a physiologically inactive compound, indicates that the enzyme responsible for this reaction, catechol-O-methyl transferase, is the enzyme mainly involved in the termination of action of epinephrine in man.

Entities:  

Keywords:  EPINEPHRINE/metabolism

Mesh：

Substances：

Year:  1958        PMID： 13580222     DOI： 10.1126/science.128.3324.593

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  25 in total

1.  TURNOVER AND METABOLISM OF CATECHOLAMINES IN PATIENTS WITH PHEOCHROMOCYTOMA.

Authors:  J R CROUT; A SJOERDSMA
Journal:  J Clin Invest       Date:  1964-01       Impact factor: 14.808

2.  URINARY EXCRETION OF NORADRENALINE AND ITS METABOLITES AT TEN-MINUTE INTERVALS AFTER INTRAVENOUS INJECTION OF DL-NORADRENALINE-2-C.

Authors:  M GOODALL; L ROSEN
Journal:  J Clin Invest       Date:  1963-10       Impact factor: 14.808

3.  FURTHER OBSERVATIONS ON THE DETERMINATION OF CATECHOLAMINE METABOLITES IN TUMOURS OF SYMPATHETIC NERVOUS SYSTEM.

Authors:  H KAESER; M BETTEX
Journal:  Arch Dis Child       Date:  1964-04       Impact factor: 3.791

4.  Metabolism of noradrenaline in the human.

Authors:  M GOODALL; N KIRSHNER; L ROSEN
Journal:  J Clin Invest       Date:  1959-04       Impact factor: 14.808

5.  THE EXCRETION OF 4-HYDROXY-3-METHOXY-MANDELIC ACID BY CHILDREN.

Authors:  T MCKENDRICK; R W EDWARDS
Journal:  Arch Dis Child       Date:  1965-08       Impact factor: 3.791

6.  The formation of an isoprenaline-like substance from adrenaline.

Authors:  K E EAKINS; M F LOCKETT
Journal:  Br J Pharmacol Chemother       Date:  1961-02

7.  Urinary output of adrenaline, noradrenaline, and 3-methoxy-4-hydroxymandelic acid following centrifugation and anticipation of centrifugation.

Authors:  M GOODALL; M L BERMAN
Journal:  J Clin Invest       Date:  1960-10       Impact factor: 14.808

8.  Metabolism of 7-H3-epinephrine-d-bitartrate in normal young men.

Authors:  E H LABROSSE; J AXELROD; I J KOPIN; S S KETY
Journal:  J Clin Invest       Date:  1961-02       Impact factor: 14.808

9.  [Catecholamine excretion in infectious diseases. I].

Authors:  H DENGLER; H KLEMM; G REICHEL
Journal:  Klin Wochenschr       Date:  1959-08-01

10.  The diagnosis of pheochromocytoma by determination of urinary 3-methoxy-4-hydroxymandelic acid.

Authors:  S E GITLOW; M MENDLOWITZ; S KHASSIS; G COHEN; J SHA
Journal:  J Clin Invest       Date:  1960-01       Impact factor: 14.808
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