Literature DB >> 1371954

Specific inhibition of mRNA accumulation for lymphokines in human T cell line Jurkat by mycobacterial lipoarabinomannan antigen.

C S Chujor1, B Kuhn, B Schwerer, H Bernheimer, W R Levis, D Bevec.   

Abstract

The immunomodulatory effect of Mycobacterium tuberculosis-derived lipoarabinomannan (LAM) on mitogen/antigen-induced expression of mRNAs for a number of cytokines in human monocytic cell line Mono-Mac-6 and in T cell line Jurkat was investigated. Interestingly, LAM exhibited a down-regulatory effect on the accumulation of mRNAs for IL-2, IL-3, granulocyte-macrophage colony-stimulating factor (GM-CSF), and IL-2 receptor alpha (IL-2R alpha) in T cells co-stimulated with phytohaemagglutinin-P (PHA) and 4 beta-phorbol-12-myristyl-13-acetate (PMA). In human Mono-Mac-6 cells. LAM has a weak inhibitory effect on the lipopolysaccharide (LPS)-induced mRNA accumulation for IL-1 beta, a slight stimulatory effect on mRNAs accumulation for IL-8 and tumour necrosis factor-alpha (TNF-alpha), but clearly no effect on mRNA accumulation for intercellular adhesion molecule-1 (ICAM-1). These findings imply that LAM may contribute to the immunologic defects associated with a number of mycobacterial infections by modulating these mediators.

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Year:  1992        PMID： 1371954      PMCID： PMC1554347          DOI： 10.1111/j.1365-2249.1992.tb03009.x

Source DB:  PubMed          Journal:  Clin Exp Immunol        ISSN： 0009-9104            Impact factor:   4.330


  26 in total

1.  Immunosuppression by mycobacterial arabinomannan.

Authors:  J J Ellner; T M Daniel
Journal:  Clin Exp Immunol       Date:  1979-02       Impact factor: 4.330

2.  Local production of tumor necrosis factor and IFN-gamma in tuberculous pleuritis.

Authors:  P F Barnes; S J Fong; P J Brennan; P E Twomey; A Mazumder; R L Modlin
Journal:  J Immunol       Date:  1990-07-01       Impact factor: 5.422

3.  The inhibitory effects of mycobacterial lipoarabinomannan and polysaccharides upon polyclonal and monoclonal human T cell proliferation.

Authors:  C Moreno; A Mehlert; J Lamb
Journal:  Clin Exp Immunol       Date:  1988-11       Impact factor: 4.330

4.  Activated suppressor T cells in leprosy.

Authors:  V Mehra; J Convit; A Rubinstein; B R Bloom
Journal:  J Immunol       Date:  1982-11       Impact factor: 5.422

5.  The suppressive effect of M. leprae on the in vitro proliferative responses of lymphocytes from patients with leprosy.

Authors:  I Nath; R Singh
Journal:  Clin Exp Immunol       Date:  1980-09       Impact factor: 4.330

6.  Defective cell-mediated immunity in leprosy: failure of T cells from lepromatous leprosy patients to respond to Mycobacterium leprae is associated with defective expression of interleukin 2 receptors and is not reconstituted by interleukin 2.

Authors:  N Mohagheghpour; R H Gelber; J W Larrick; D T Sasaki; P J Brennan; E G Engleman
Journal:  J Immunol       Date:  1985-08       Impact factor: 5.422

7.  Lipoarabinomannan from Mycobacterium tuberculosis induces the production of tumour necrosis factor from human and murine macrophages.

Authors:  C Moreno; J Taverne; A Mehlert; C A Bate; R J Brealey; A Meager; G A Rook; J H Playfair
Journal:  Clin Exp Immunol       Date:  1989-05       Impact factor: 4.330

8.  Mycobacterium leprae antigen-induced suppression of T cell proliferation in vitro.

Authors:  G Kaplan; R R Gandhi; D E Weinstein; W R Levis; M E Patarroyo; P J Brennan; Z A Cohn
Journal:  J Immunol       Date:  1987-05-01       Impact factor: 5.422

9.  Lipoarabinomannan, a possible virulence factor involved in persistence of Mycobacterium tuberculosis within macrophages.

Authors:  J Chan; X D Fan; S W Hunter; P J Brennan; B R Bloom
Journal:  Infect Immun       Date:  1991-05       Impact factor: 3.441

10.  Defective gamma interferon production in leprosy. Reversal with antigen and interleukin 2.

Authors:  N Nogueira; G Kaplan; E Levy; E N Sarno; P Kushner; A Granelli-Piperno; L Vieira; V Colomer Gould; W Levis; R Steinman
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4.  A mycobacterial lipoarabinomannan specific monoclonal antibody and its F(ab') fragment prolong survival of mice infected with Mycobacterium tuberculosis.

Authors:  B Hamasur; M Haile; A Pawlowski; U Schroder; G Kallenius; S B Svenson
Journal:  Clin Exp Immunol       Date:  2004-10       Impact factor: 4.330

5.  Mycobacterial lipoarabinomannan induces nitric oxide and tumor necrosis factor alpha production in a macrophage cell line: down regulation by taurine chloramine.

Authors:  G B Schuller-Levis; W R Levis; M Ammazzalorso; A Nosrati; E Park
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Authors:  R Schreck; D Bevec; P Dukor; P A Baeuerle; L Chedid; G M Bahr
Journal:  Clin Exp Immunol       Date:  1992-11       Impact factor: 4.330

7.  Cellular and humoral immune responses to recombinant 65-kD antigen of Mycobacterium leprae in leprosy patients and healthy controls.

Authors:  S Ilangumaran; N P Shanker Narayan; G Ramu; V R Muthukkaruppan
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8.  Expression of functional high affinity immunoglobulin E receptors (Fc epsilon RI) on monocytes of atopic individuals.

Authors:  D Maurer; E Fiebiger; B Reininger; B Wolff-Winiski; M H Jouvin; O Kilgus; J P Kinet; G Stingl
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