Literature DB >> 13715260

Evaluation of antagonists of histamine, 5-hydroxytryptamine and acetylcholine in the guinea-pig.

J A HOLGATE, B T WARNER.   

Abstract

Changes in the resistance to entry of air into the lungs of anaesthetized guinea-pigs have been used to study the effects of histamine, 5-hydroxytryptamine, and acetylcholine. Some known antagonists of these bronchoconstrictor agents have been investigated. The degree of antagonism has been expressed in terms of the dose ratio, previously used only with in vitro preparations.

Entities:  

Keywords:  ACETYLCHOLINE/antagonists; ATROPINE/pharmacology; LYSERGIC ACID DIETHYLAMIDE/pharmacology; RESPIRATORY SYSTEM/pharmacology

Mesh：

Substances：

Year:  1960        PMID： 13715260      PMCID： PMC1482269          DOI： 10.1111/j.1476-5381.1960.tb00282.x

Source DB:  PubMed          Journal:  Br J Pharmacol Chemother        ISSN： 0366-0826


  5 in total

1.  Quantitative studies of antagonists for 5-hydroxytryptamine.

Authors:  J H GADDUM; K A HAMEED; D E HATHWAY; F F STEPHENS
Journal:  Q J Exp Physiol Cogn Med Sci       Date:  1955-01

2.  The bronchoconstrictor action of bradykinin in the guinea-pig.

Authors:  H O COLLIER; J A HOLGATE; M SCHACHTER; P G SHORLEY
Journal:  Br J Pharmacol Chemother       Date:  1960-06

3.  The effects of 5-hydroxytryptamine and its antagonists on tidal air.

Authors:  H KONZETT
Journal:  Br J Pharmacol Chemother       Date:  1956-09

4.  Superfusion as a method for the study of drug antagonism.

Authors:  G W CAMBRIDGE; J A HOLGATE
Journal:  Br J Pharmacol Chemother       Date:  1955-09

5.  Two kinds of tryptamine receptor.

Authors:  J H GADDUM; Z P PICARELLI
Journal:  Br J Pharmacol Chemother       Date:  1957-09
  5 in total
  5 in total

1.  The role of pharmacologically-active amines in resistance to Trichostrongylus colubriformis in the guinea-pig.

Authors:  T L Rothwell; J K Dineen; R J Love
Journal:  Immunology       Date:  1971-12       Impact factor: 7.397

2.  Humoral factors affecting pulmonary inflation during acute anaphylaxis in the guinea-pig in vivo.

Authors:  H O Collier; G W James
Journal:  Br J Pharmacol Chemother       Date:  1967-06

3.  Response of rat lung to humoral mediators of anaphylaxis and its modification by drugs and sensitization.

Authors:  M K Church
Journal:  Br J Pharmacol       Date:  1975-11       Impact factor: 8.739

4.  Pharmacological analysis of histamine receptors in musculature and vasculature of the dog trachea in situ.

Authors:  N Himori; N Taira
Journal:  Br J Pharmacol       Date:  1978-12       Impact factor: 8.739

5.  Comparative responses of tracheal spirals and parenchymal strips to histamine and carbachol in vitro.

Authors:  J M Drazen; M W Schneider
Journal:  J Clin Invest       Date:  1978-06       Impact factor: 14.808
  5 in total

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