Literature DB >> 1370088

Influenza A virus transfectants with chimeric hemagglutinins containing epitopes from different subtypes.

S Q Li1, J L Schulman, T Moran, C Bona, P Palese.   

Abstract

Influenza virus transfectants with chimeric hemagglutinins were constructed by using a ribonucleoprotein transfection method. Transfectants W(H1)-H2 and W(H1)-H3 contained A/WSN/33(H1N1) (WSN) hemagglutinins in which the six-amino-acid loop (contained in antigenic site B) was replaced by the corresponding structures of influenza viruses A/Japan/57(H2N2) and A/Hong Kong/8/68(H3N2) (HK), respectively. Serological analysis indicated that the W(H1)-H3 transfectant virus reacted with antibodies against both the WSN and HK viruses in hemagglutination inhibition and plaque neutralization assays. Furthermore, mice immunized with W(H1)-H3 transfectant virus produced antibodies to the WSN and HK viruses. The results demonstrate that influenza virus transfectants can be engineered to express epitopes of different subtypes on their hemagglutinins.

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Year:  1992        PMID： 1370088      PMCID： PMC238299     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  15 in total

1.  Molecular characterization of a new hemagglutinin, subtype H14, of influenza A virus.

Authors:  Y Kawaoka; S Yamnikova; T M Chambers; D K Lvov; R G Webster
Journal:  Virology       Date:  1990-12       Impact factor: 3.616

2.  Amplification, expression, and packaging of foreign gene by influenza virus.

Authors:  W Luytjes; M Krystal; M Enami; J D Parvin; P Palese
Journal:  Cell       Date:  1989-12-22       Impact factor: 41.582

3.  Antigen chimaeras of poliovirus as potential new vaccines.

Authors:  K L Burke; G Dunn; M Ferguson; P D Minor; J W Almond
Journal:  Nature       Date:  1988-03-03       Impact factor: 49.962

4.  An influenza A virus containing influenza B virus 5' and 3' noncoding regions on the neuraminidase gene is attenuated in mice.

Authors:  T Muster; E K Subbarao; M Enami; B R Murphy; P Palese
Journal:  Proc Natl Acad Sci U S A       Date:  1991-06-15       Impact factor: 11.205

5.  Vaccines for the Third World.

Authors:  B R Bloom
Journal:  Nature       Date:  1989-11-09       Impact factor: 49.962

6.  The antigenic structure of the influenza virus A/PR/8/34 hemagglutinin (H1 subtype).

Authors:  A J Caton; G G Brownlee; J W Yewdell; W Gerhard
Journal:  Cell       Date:  1982-12       Impact factor: 41.582

7.  Cloning and DNA sequence of double-stranded copies of haemagglutinin genes from H2 and H3 strains elucidates antigenic shift and drift in human influenza virus.

Authors:  M J Gething; J Bye; J Skehel; M Waterfield
Journal:  Nature       Date:  1980-09-25       Impact factor: 49.962

8.  High-efficiency formation of influenza virus transfectants.

Authors:  M Enami; P Palese
Journal:  J Virol       Date:  1991-05       Impact factor: 5.103

9.  An engineered poliovirus chimaera elicits broadly reactive HIV-1 neutralizing antibodies.

Authors:  D J Evans; J McKeating; J M Meredith; K L Burke; K Katrak; A John; M Ferguson; P D Minor; R A Weiss; J W Almond
Journal:  Nature       Date:  1989-06-01       Impact factor: 49.962

10.  Introduction of site-specific mutations into the genome of influenza virus.

Authors:  M Enami; W Luytjes; M Krystal; P Palese
Journal:  Proc Natl Acad Sci U S A       Date:  1990-05       Impact factor: 11.205
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  25 in total

1.  Mutational analysis of the promoter required for influenza virus virion RNA synthesis.

Authors:  X Li; P Palese
Journal:  J Virol       Date:  1992-07       Impact factor: 5.103

2.  Reverse genetics system for generation of an influenza A virus mutant containing a deletion of the carboxyl-terminal residue of M2 protein.

Authors:  M R Castrucci; Y Kawaoka
Journal:  J Virol       Date:  1995-05       Impact factor: 5.103

3.  Protection against lethal lymphocytic choriomeningitis virus (LCMV) infection by immunization of mice with an influenza virus containing an LCMV epitope recognized by cytotoxic T lymphocytes.

Authors:  M R Castrucci; S Hou; P C Doherty; Y Kawaoka
Journal:  J Virol       Date:  1994-06       Impact factor: 5.103

Review 4.  RNA virus vectors: where are we and where do we need to go?

Authors:  P Palese
Journal:  Proc Natl Acad Sci U S A       Date:  1998-10-27       Impact factor: 11.205

5.  Influenza viruses expressing chimeric hemagglutinins: globular head and stalk domains derived from different subtypes.

Authors:  Rong Hai; Florian Krammer; Gene S Tan; Natalie Pica; Dirk Eggink; Jad Maamary; Irina Margine; Randy A Albrecht; Peter Palese
Journal:  J Virol       Date:  2012-03-07       Impact factor: 5.103

6.  Expression of a foreign protein by influenza A virus.

Authors:  N Percy; W S Barclay; A García-Sastre; P Palese
Journal:  J Virol       Date:  1994-07       Impact factor: 5.103

7.  Influenza A virus hemagglutinin is a B cell-superstimulatory lectin.

Authors:  O Rott; J Charreire; E Cash
Journal:  Med Microbiol Immunol       Date:  1996-02       Impact factor: 3.402

8.  Priming with recombinant influenza virus followed by administration of recombinant vaccinia virus induces CD8+ T-cell-mediated protective immunity against malaria.

Authors:  S Li; M Rodrigues; D Rodriguez; J R Rodriguez; M Esteban; P Palese; R S Nussenzweig; F Zavala
Journal:  Proc Natl Acad Sci U S A       Date:  1993-06-01       Impact factor: 11.205

9.  Chimeric influenza virus induces neutralizing antibodies and cytotoxic T cells against human immunodeficiency virus type 1.

Authors:  S Li; V Polonis; H Isobe; H Zaghouani; R Guinea; T Moran; C Bona; P Palese
Journal:  J Virol       Date:  1993-11       Impact factor: 5.103

10.  Rescue of an influenza A virus wild-type PB2 gene and a mutant derivative bearing a site-specific temperature-sensitive and attenuating mutation.

Authors:  E K Subbarao; Y Kawaoka; B R Murphy
Journal:  J Virol       Date:  1993-12       Impact factor: 5.103
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