METHODS: A retrospective study regarding the relationship between serum hormonal levels and bone mineral density (BMD) was performed in 125 women with hormone replacement therapy (HRT). Serum estradiol (E(2)), luteinizing hormone (LH), follicle-stimulating hormone (FSH), and BMD were evaluated before and at 12 and 24 months of HRT. RESULTS: There was a significant increase in E(2) and decrease in FSH at both 12 (E(2), 39.3+/-76.6 pg/ml to 71.0+/-67.9 pg/ml; FSH, 67.9+/-36.3 mIU/ml to 47.9+/-29.0 mIU/ml) and 24 months (E(2), 68.3+/-54.5 pg/ml; FSH, 45.3+/-24.4 mIU/ml). LH level was high at baseline (26.5+/-16.1 mIU/ml) and decreased at 12 months (22.9+/-14.0 mIU/ml). On the contrary, it increased from 12 to 24 months (27.4+/-14.9 mIU/ml). In the lumbar spine BMD, a significant rise was seen only in the first 12 months (0.933+/-0.157 g/cm(2) to 0.938+/-0.152 g/cm(2)). When percentage change was analyzed, a significant positive correlation was found between E(2) and BMD and a negative correlation between gonadotropin levels and BMD. CONCLUSION: These data demonstrate that serum gonadotropin levels, especially FSH, are a good marker to predict BMD in women with HRT.
METHODS: A retrospective study regarding the relationship between serum hormonal levels and bone mineral density (BMD) was performed in 125 women with hormone replacement therapy (HRT). Serum estradiol (E(2)), luteinizing hormone (LH), follicle-stimulating hormone (FSH), and BMD were evaluated before and at 12 and 24 months of HRT. RESULTS: There was a significant increase in E(2) and decrease in FSH at both 12 (E(2), 39.3+/-76.6 pg/ml to 71.0+/-67.9 pg/ml; FSH, 67.9+/-36.3 mIU/ml to 47.9+/-29.0 mIU/ml) and 24 months (E(2), 68.3+/-54.5 pg/ml; FSH, 45.3+/-24.4 mIU/ml). LH level was high at baseline (26.5+/-16.1 mIU/ml) and decreased at 12 months (22.9+/-14.0 mIU/ml). On the contrary, it increased from 12 to 24 months (27.4+/-14.9 mIU/ml). In the lumbar spine BMD, a significant rise was seen only in the first 12 months (0.933+/-0.157 g/cm(2) to 0.938+/-0.152 g/cm(2)). When percentage change was analyzed, a significant positive correlation was found between E(2) and BMD and a negative correlation between gonadotropin levels and BMD. CONCLUSION: These data demonstrate that serum gonadotropin levels, especially FSH, are a good marker to predict BMD in women with HRT.
Authors: Peng Liu; Yaoting Ji; Tony Yuen; Elizabeth Rendina-Ruedy; Victoria E DeMambro; Samarth Dhawan; Wahid Abu-Amer; Sudeh Izadmehr; Bin Zhou; Andrew C Shin; Rauf Latif; Priyanthan Thangeswaran; Animesh Gupta; Jianhua Li; Valeria Shnayder; Samuel T Robinson; Yue Eric Yu; Xingjian Zhang; Feiran Yang; Ping Lu; Yu Zhou; Ling-Ling Zhu; Douglas J Oberlin; Terry F Davies; Michaela R Reagan; Aaron Brown; T Rajendra Kumar; Solomon Epstein; Jameel Iqbal; Narayan G Avadhani; Maria I New; Henrik Molina; Jan B van Klinken; Edward X Guo; Christoph Buettner; Shozeb Haider; Zhuan Bian; Li Sun; Clifford J Rosen; Mone Zaidi Journal: Nature Date: 2017-05-24 Impact factor: 49.962
Authors: Mone Zaidi; Maria I New; Harry C Blair; Alberta Zallone; Ramkumarie Baliram; Terry F Davies; Christopher Cardozo; James Iqbal; Li Sun; Clifford J Rosen; Tony Yuen Journal: J Endocrinol Date: 2018-03-19 Impact factor: 4.286