Literature DB >> 13680213

Thrombin induces Sp1-mediated antiviral effects in cytomegalovirus-infected human retinal pigment epithelial cells.

Martin Scholz1, Jens-Uwe Vogel, Gerold Höver, Susanna Prösch, Ruslan Kotchetkov, Jaroslav Cinatl, Frank Koch, Hans Wilhelm Doerr, Jindrich Cinatl.   

Abstract

Human cytomegalovirus (HCMV) retinitis causing retinal detachment and destruction of the blood-retina barrier is closely related to retinal hemorrhage/coagulation. However, the effects of procoagulants on HCMV (re)activation in retinal cells have not been investigated yet. Therefore, we studied whether thrombin modulates the expression of HCMV immediate early (IE) and late (L) genes in cultured human retinal pigment epithelial cells (RPE). Thrombin specifically stimulated the protease-activated receptor-1 (PAR-1) on RPE and, surprisingly, inhibited basal and 12,0-tetradecanoylphorbol 13-acetate-stimulated HCMV IE gene expression in infected RPE. On the other hand, HCMV strongly induced Sp1 DNA binding activity, which was prevented by thrombin/PAR1-mediated Sp1 hyperphosphorylation. Our data suggest that thrombin/PAR-1 may inhibit Sp1-dependent HCMV replication, which might be an important regulatory mechanism for HCMV persistence and replication in RPE.

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Year:  2003        PMID： 13680213     DOI： 10.1007/s00430-003-0194-x

Source DB:  PubMed          Journal:  Med Microbiol Immunol        ISSN： 0300-8584            Impact factor:   3.402


  51 in total

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2.  A novel role for Gq alpha in alpha-thrombin-mediated mitogenic signalling pathways.

Authors:  Alice Gardner; Polly J Phillips-Mason; Daniel M Raben; Joseph J Baldassare
Journal:  Cell Signal       Date:  2002-06       Impact factor: 4.315

3.  Thrombin-antithrombin III complex in acute retinal vein occlusion.

Authors:  H Iijima; T Gohdo; M Imai; S Tsukahara
Journal:  Am J Ophthalmol       Date:  1998-11       Impact factor: 5.258

4.  Human cytomegalovirus ie1 transactivates the alpha promoter-enhancer via an 18-base-pair repeat element.

Authors:  J M Cherrington; E S Mocarski
Journal:  J Virol       Date:  1989-03       Impact factor: 5.103

Review 5.  The role of Fas ligand in immune privilege.

Authors:  D R Green; T A Ferguson
Journal:  Nat Rev Mol Cell Biol       Date:  2001-12       Impact factor: 94.444

6.  Induction of the transcription factor Sp1 during human cytomegalovirus infection mediates upregulation of the p65 and p105/p50 NF-kappaB promoters.

Authors:  A D Yurochko; M W Mayo; E E Poma; A S Baldwin; E S Huang
Journal:  J Virol       Date:  1997-06       Impact factor: 5.103

7.  Postmortem histological survey of the ocular lesions in a British population of AIDS patients.

Authors:  I Pecorella; A Ciardi; A Garner; A C McCartney; S Lucas
Journal:  Br J Ophthalmol       Date:  2000-11       Impact factor: 4.638

8.  Decreased neutrophil adhesion to human cytomegalovirus-infected retinal pigment epithelial cells is mediated by virus-induced up-regulation of Fas ligand independent of neutrophil apoptosis.

Authors:  J Cinatl; R Blaheta; M Bittoova; M Scholz; S Margraf; J U Vogel; J Cinatl; H W Doerr
Journal:  J Immunol       Date:  2000-10-15       Impact factor: 5.422

Review 9.  Characteristics of cytomegalovirus retinitis in patients with acquired immunodeficiency syndrome.

Authors:  M H Heinemann
Journal:  Am J Med       Date:  1992-02-14       Impact factor: 4.965

10.  Tumour necrosis factor alpha stimulates the activity of the human cytomegalovirus major immediate early enhancer/promoter in immature monocytic cells.

Authors:  J Stein; H D Volk; C Liebenthal; D H Krüger; S Prösch
Journal:  J Gen Virol       Date:  1993-11       Impact factor: 3.891
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  5 in total

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2.  Epidemiology of human cytomegalovirus (HCMV) in an urban region of Germany: what has changed?

Authors:  Paul R Lübeck; Hans Wilhelm Doerr; Holger F Rabenau
Journal:  Med Microbiol Immunol       Date:  2009-12-01       Impact factor: 3.402

3.  Activated protein C therapy slows ALS-like disease in mice by transcriptionally inhibiting SOD1 in motor neurons and microglia cells.

Authors:  Zhihui Zhong; Hristelina Ilieva; Lee Hallagan; Robert Bell; Itender Singh; Nicole Paquette; Meenakshisundaram Thiyagarajan; Rashid Deane; Jose A Fernandez; Steven Lane; Anna B Zlokovic; Todd Liu; John H Griffin; Nienwen Chow; Francis J Castellino; Konstantin Stojanovic; Don W Cleveland; Berislav V Zlokovic
Journal:  J Clin Invest       Date:  2009-10-19       Impact factor: 14.808

4.  Protease-activated receptor 1 inhibition protects mice against thrombin-dependent respiratory syncytial virus and human metapneumovirus infections.

Authors:  Vuong Ba Lê; Béatrice Riteau; Marie-Christine Alessi; Christian Couture; Martine Jandrot-Perrus; Chantal Rhéaume; Marie-Ève Hamelin; Guy Boivin
Journal:  Br J Pharmacol       Date:  2017-12-10       Impact factor: 8.739

5.  The role of protease-activated receptor 1 signaling in CD8 T cell effector functions.

Authors:  Hui Chen; Mindy Smith; Jasmin Herz; Tong Li; Rebecca Hasley; Cecile Le Saout; Ziang Zhu; Jie Cheng; Andres Gronda; José A Martina; Pablo M Irusta; Tatiana Karpova; Dorian B McGavern; Marta Catalfamo
Journal:  iScience       Date:  2021-10-30
  5 in total

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