BACKGROUND: The purpose of this study was to evaluate to what extent self-reported health related quality of life (HRQL), assessed by the Swedish standard version of the Medical Outcome Study Short-Form 36 (SF-36), is related to measured exercise capacity and metabolic efficiency in a cohort of healthy subjects from the Gothenburg area of Sweden. MATERIAL AND METHODS: Individuals were invited to take part in the evaluation where HRQL was compared with the maximal power output expressed in Watts assessed during a standardized treadmill test with incremental work loads. Whole body respiratory gas exchanges (CO2/O2) were simultaneously measured. Estimate of metabolic efficiency was derived from oxygen uptake per Watt produced (ml O2/min/W) near maximal work. RESULTS: The health status profile in the current population largely agreed with normative data from an age- and gender-matched reference group, although some measured scores were slightly better than reference scores. Males and females had a similar relationship between energy cost (ml O2/min) for production of maximal work (W), while the regressions for maximal exercise power and age were significantly different between males and females (p < 0.01). The overall metabolic efficiency was the same in individuals between 40 and 74 years of age (10.4 +/- 0.07 ml O2/min/ Watt). Maximal exercise power was only related to the SF-36 subscale physical functioning (PF), but unrelated to other physical subscales such as role limitations due to physical problems, good general health and vitality. There was also a discrepancy between measured maximal power and PF in many subjects, particularly in males who experienced either intact or severely reduced PF. CONCLUSIONS: Our results demonstrate that simultaneous measurements of self-reported and objective measures of PF should add a more integrated view for evaluation of therapeutic effectiveness, since the overall correlation was poor between objective and subjective scores among individuals.
BACKGROUND: The purpose of this study was to evaluate to what extent self-reported health related quality of life (HRQL), assessed by the Swedish standard version of the Medical Outcome Study Short-Form 36 (SF-36), is related to measured exercise capacity and metabolic efficiency in a cohort of healthy subjects from the Gothenburg area of Sweden. MATERIAL AND METHODS: Individuals were invited to take part in the evaluation where HRQL was compared with the maximal power output expressed in Watts assessed during a standardized treadmill test with incremental work loads. Whole body respiratory gas exchanges (CO2/O2) were simultaneously measured. Estimate of metabolic efficiency was derived from oxygen uptake per Watt produced (ml O2/min/W) near maximal work. RESULTS: The health status profile in the current population largely agreed with normative data from an age- and gender-matched reference group, although some measured scores were slightly better than reference scores. Males and females had a similar relationship between energy cost (ml O2/min) for production of maximal work (W), while the regressions for maximal exercise power and age were significantly different between males and females (p < 0.01). The overall metabolic efficiency was the same in individuals between 40 and 74 years of age (10.4 +/- 0.07 ml O2/min/ Watt). Maximal exercise power was only related to the SF-36 subscale physical functioning (PF), but unrelated to other physical subscales such as role limitations due to physical problems, good general health and vitality. There was also a discrepancy between measured maximal power and PF in many subjects, particularly in males who experienced either intact or severely reduced PF. CONCLUSIONS: Our results demonstrate that simultaneous measurements of self-reported and objective measures of PF should add a more integrated view for evaluation of therapeutic effectiveness, since the overall correlation was poor between objective and subjective scores among individuals.
Authors: C Taft; J Karlsson; J Gelin; L Jivegård; R Sandström; B Arfvidsson; A G Dahllöf; K Lundholm; M Sullivan Journal: Eur J Vasc Endovasc Surg Date: 2001-08 Impact factor: 7.069
Authors: P Daneryd; E Svanberg; U Körner; E Lindholm; R Sandström; H Brevinge; C Pettersson; I Bosaeus; K Lundholm Journal: Cancer Res Date: 1998-12-01 Impact factor: 12.701
Authors: Kathryn P Altizer; Ha T Nguyen; Rebecca H Neiberg; Sara A Quandt; Joseph G Grzywacz; Wei Lang; Ronny A Bell; Thomas A Arcury Journal: J Appl Gerontol Date: 2012-08-01
Authors: Morgan N Clennin; Jonathan P W Payne; Edgardo G Rienzi; Carl J Lavie; Steven N Blair; Russell R Pate; Xuemei Sui Journal: PLoS One Date: 2015-04-22 Impact factor: 3.240
Authors: Sebastian Kummer; Anna Stahl-Pehe; Katty Castillo; Christina Bächle; Christine Graf; Klaus Straßburger; Burak Salgin; Ertan Mayatepek; Guido Giani; Reinhard W Holl; Thomas Meissner; Joachim Rosenbauer Journal: PLoS One Date: 2014-11-10 Impact factor: 3.240