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Literature DB >> 1366609

The effect of neutral resins on the fermentation production of rubradirin.

V P Marshall¹, S J McWethy, J M Sirotti, J I Cialdella.

Abstract

Rubradirin is an antibiotic of complex chemical structure which is active vs. methicillin resistant staphylococci. Its development has been limited due to inadequate production yields. The incorporation of neutral resins into fermentations of Streptomyces achromogenes v. rubradiris, UC 8051 resulted in the enhanced production of rubradirin. Resins HP-20, HP-21, XAD-2, XAD-7 and XAD-16 were employed in flask and tank fermentations. The incorporation of these resins promoted 2- to 4-fold enhancements of the rubradirin activity produced in flask fermentations, and the incorporation of XAD-16 and HP-21 into tank fermentations promoted production titer increases greater than 5 fold.

Entities: Chemical Species

Mesh：

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Year: 1990 PMID： 1366609 DOI： 10.1007/bf01578202

Source DB: PubMed Journal: J Ind Microbiol ISSN： 0169-4146

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1. Characterization of product capture resin during microbial cultivations.

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4. Extractive fermentation for enhanced production of thailandepsin A from Burkholderia thailandensis E264 using polyaromatic adsorbent resin Diaion HP-20.

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The effect of neutral resins on the fermentation production of rubradirin.

1. A new process and organism for the fermentation production of volonomycin.

1. Characterization of product capture resin during microbial cultivations.

2. Fermentative production of self-toxic fungal secondary metabolites.

Review 3. Use of in situ solid-phase adsorption in microbial natural product fermentation development.

4. Extractive fermentation for enhanced production of thailandepsin A from Burkholderia thailandensis E264 using polyaromatic adsorbent resin Diaion HP-20.

5. Isolation and characterization of tirandamycins from a marine-derived Streptomyces sp.

6. The effect of cerulenin on the production of esperamicin A1 by Actinomadura verrucosospora.

7. Assessing the effects of adsorptive polymeric resin additions on fungal secondary metabolite chemical diversity.

8. In-Situ Recovery of Persipeptides from Streptomyces zagrosensis Fermentation Broth by Enhanced Adsorption.

9. Extending the Metabolite Diversity of the Endophyte Dimorphosporicola tragani.