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Literature DB >> 13664865

Macroglobulinemia. III. The effect of mercaptoethanol on the antigenic structure of macroglobulins.

Abstract

The monomers obtained by treating gamma(1)-macroglobulins with mercaptoethanol have proved to be antigenically different from normal 7S 7gamma-globulin. The depolymerization of the macroglobulins resulted in the loss of several antigenic determinants, although the monomers still cross-reacted with antisera against macroglobulins. Reaggregation of the monomers occasionally resulted in the reconstitution of some or all of the antigenic determinants that were lost during depolymerization. Repeated freezing and thawing of pathological macroglobulins in iodoacetate resulted in their complete antigenic destruction. Repeated freezing and thawing of one of the monomers in excess iodoacetate resulted in the degradation to a protein antigenically indistinguishable from Bence Jones protein. The other two monomers studied were stable under these conditions.

Entities: Chemical Disease

Keywords: ALCOHOL, ETHYL/related compounds; SERUM GLOBULIN/effect of drugs on; SULFHYDRYL COMPOUNDS/effects

Mesh：

Substances：

Year: 1959 PMID： 13664865 PMCID： PMC2136966 DOI： 10.1084/jem.110.1.1

Source DB: PubMed Journal: J Exp Med ISSN： 0022-1007 Impact factor: 14.307

14 in total

8. The isolation and properties of a fragment of bovine-serum albumin which retains the ability to combine with rabbit antiserum.

Authors: R R PORTER
Journal: Biochem J Date: 1957-08 Impact factor: 3.857

9. Multiple-myeloma proteins. III. The antigenic relationship of Bence Jones proteins to normal gammaglobulin and multiple-myeloma serum proteins.

Authors: L KORNGOLD; R LIPARI
Journal: Cancer Date: 1956 Mar-Apr Impact factor: 6.860

10. Macroglobulinemia. I. The antigenic relationship of pathological macroglobulins to normal gamma-globulins.

Authors: L KORNGOLD; G VAN LEEUWEN
Journal: J Exp Med Date: 1957-10-01 Impact factor: 14.307

6 in total

1. [STUDIES ON THE DISSOCIATION OF GAMMA-1-MACROGLOBULINS BY CYSTEAMINE. I. SEDIMENTATION ANALYSIS AND VISCOSIMETRIC STUDIES].

Authors: F W TISCHENDORF; P G SCHEURLEN; E KALLEE
Journal: Klin Wochenschr Date: 1965-05-01

2. Immunochemical studies of human serum proteins. Antigenic inhomogeneities of the gamma globulins, their subunits and number of determinants and their relation to a Waldenstrom macroglobulin.

Authors: R AUGUSTIN; B J HAYWARD
Journal: Immunology Date: 1961-10 Impact factor: 7.397

Macroglobulinemia. III. The effect of mercaptoethanol on the antigenic structure of macroglobulins.

1. [Immunochemical and immunoelectrophoretic studies in macroglobulinemia].

2. The effect of the antigen's molecular weight on the curvature of the precipitin line in the Ouchterlony technic.

3. A serologic investigation of Waldenström's macroglobulinemia by means of the agar diffusion method.

4. Immunologic differences between the 19 S and 7 S components of normal human gamma-globulin.

5. Dissociation of human serum macroglobulins.

6. Proteins in multiple myeloma. VII. The free amino groups of Bence-Jones proteins.

7. A cryoglobulin with unusual characteristics associated with a rare hematologic disorder.

8. The isolation and properties of a fragment of bovine-serum albumin which retains the ability to combine with rabbit antiserum.

9. Multiple-myeloma proteins. III. The antigenic relationship of Bence Jones proteins to normal gammaglobulin and multiple-myeloma serum proteins.

10. Macroglobulinemia. I. The antigenic relationship of pathological macroglobulins to normal gamma-globulins.

1. [STUDIES ON THE DISSOCIATION OF GAMMA-1-MACROGLOBULINS BY CYSTEAMINE. I. SEDIMENTATION ANALYSIS AND VISCOSIMETRIC STUDIES].

2. Immunochemical studies of human serum proteins. Antigenic inhomogeneities of the gamma globulins, their subunits and number of determinants and their relation to a Waldenstrom macroglobulin.

3. Some factors affecting precipitation and complex formation of an IgG cryoglobulin.

4. [On the differentiation of the so-called "depot-spot" in immunoelectrophoresis].

5. [Studies on the dissociation of gamma-1-macroglobulins by cysteamine. II. Electrophoretic findings].

6. Papain digestion fragments of human IgM globulins.