| Literature DB >> 1366359 |
T A Bühler1, T Bruyère, D F Went, G Stranzinger, K Bürki.
Abstract
To test the potential usefulness of transgenic rabbits as production systems for human proteins of pharmaceutical value, we cloned the rabbit beta-casein promoter and fused it to the genomic sequence of the human interleukin-2 (hIL2) gene. Four transgenic female rabbits were tested for expression and biological activity of the foreign protein in their milk. The milk of all four females proved to contain biologically active hIL2. The results show that transgenic rabbits may represent a convenient and economic system for the rapid production of biologically active protein in milk.Entities:
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Year: 1990 PMID： 1366359 DOI： 10.1038/nbt0290-140
Source DB: PubMed Journal: Biotechnology (N Y) ISSN： 0733-222X