Literature DB >> 13651586

The effects of reserpine and other agents upon leptazol convulsions in mice.

A W LESSIN, M W PARKES.   

Abstract

Reserpine and tetrabenazine reduced the survival time of mice infused with leptazol. This effect was antagonized by pretreatment with iproniazid. The survival time of iproniazid-treated mice was prolonged by 5-hydroxytryptophan but not by 3:4-dihydroxyphenylalanine. These findings suggest a relation between leptazol sensitivity and brain levels of 5-hydroxytryptamine.

Entities:  

Keywords:  CONVULSIONS/experimental; PENTYLENETETRAZOLE/effects; RESERPINE/effects

Mesh：

Substances：

Year:  1959        PMID： 13651586      PMCID： PMC1481814          DOI： 10.1111/j.1476-5381.1959.tb00935.x

Source DB:  PubMed          Journal:  Br J Pharmacol Chemother        ISSN： 0366-0826


  13 in total

1.  [Effect of isonicotinic acid hydrazide on the central action of reserpine and 5-hydroxytryptamine].

Authors:  H BESENDORF; A PLETSCHER
Journal:  Helv Physiol Pharmacol Acta       Date:  1956

2.  The antagonism of reserpine hypothermia by iproniazid.

Authors:  A N DAVISON; A W LESSIN; M W PARKES
Journal:  Experientia       Date:  1957-08-15

3.  Effect of iproniazid on serotonin metabolism in vivo.

Authors:  S UDENFRIEND; H WEISSBACH; D F BOGDANSKI
Journal:  J Pharmacol Exp Ther       Date:  1957-06       Impact factor: 4.030

4.  3,4-Dihydroxyphenylalanine and 5-hydroxytryptophan as reserpine antagonists.

Authors:  A CARLSSON; M LINDQVIST; T MAGNUSSON
Journal:  Nature       Date:  1957-11-30       Impact factor: 49.962

5.  [The EEG in vascular processes].

Authors:  H LECHNER
Journal:  Wien Klin Wochenschr       Date:  1958-02-07       Impact factor: 1.704

6.  Role of 5-hydroxytryptamine in mental diseases and its antagonism to lysergic acid derivatives.

Authors:  A CERLETTI; E ROTHLIN
Journal:  Nature       Date:  1955-10-22       Impact factor: 49.962

7.  [Effects of isonicotinic acid hydrazide on 5-hydroxytryptamine metabolism in brain].

Authors:  A PLETSCHER
Journal:  Experientia       Date:  1956-12-15

8.  Serotonin as a mediator of reserpine action in brain.

Authors:  A PLETSCHER; P A SHORE; B B BRODIE
Journal:  J Pharmacol Exp Ther       Date:  1956-01       Impact factor: 4.030

9.  A facilitation action of reserpine on the central nervous system.

Authors:  G CHEN; C R ENSOR; B BOHNER
Journal:  Proc Soc Exp Biol Med       Date:  1954-07

10.  The relation between sedation and body temperature in the mouse.

Authors:  A W LESSIN; M W PARKES
Journal:  Br J Pharmacol Chemother       Date:  1957-06
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  4 in total

1.  CENTRAL STIMULANT ACTIONS OF ALPHA-ALKYL SUBSTITUTED TRYPTAMINES IN MICE.

Authors:  A W LESSIN; R F LONG; M W PARKES
Journal:  Br J Pharmacol Chemother       Date:  1965-02

2.  Involvement of central cholinoceptors in Metrazol-induced convulsions.

Authors:  S K Rastogi; J N Puri; J N Sinha; K P Bhargava
Journal:  Psychopharmacology (Berl)       Date:  1979-10       Impact factor: 4.530

3.  The effects of intracerebroventricularly administered noradnamine and other sympathomimetic amines upon leptazol convulsions in mice.

Authors:  B J Jones; D J Roberts
Journal:  Br J Pharmacol       Date:  1968-09       Impact factor: 8.739

4.  Serotonin metabolism with idiopathic grand mal seizures.

Authors:  D R Matz; L H Rolf; G G Brune
Journal:  J Neurol       Date:  1978-12-22       Impact factor: 4.849
  4 in total

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