Literature DB >> 4877601

The effects of intracerebroventricularly administered noradnamine and other sympathomimetic amines upon leptazol convulsions in mice.

B J Jones, D J Roberts.   

Abstract

1. The influence of some intracerebroventricularly administered sympathomimetic amines on leptazol-induced convulsions has been investigated.2. Noradnamine and high doses of dopamine proved to be anticonvulsant and also antagonized the facilitative effects of reserpine.3. Noradrenaline and octopamine also antagonized reserpine-induced facilitation but were without effect on leptazol alone; by contrast tyramine and small doses of dopamine lowered the threshold for leptazol convulsions.4. A possible interpretation of these results is presented.

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Year:  1968        PMID： 4877601      PMCID： PMC1703447          DOI： 10.1111/j.1476-5381.1968.tb07946.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  23 in total

1.  Release of serotonin and catecholamines by drugs.

Authors:  P A SHORE
Journal:  Pharmacol Rev       Date:  1962-12       Impact factor: 25.468

2.  Anticonvulsant properties of monoamine oxidase inhibitors.

Authors:  D J PROCKOP; P A SHORE; B B BRODIE
Journal:  Ann N Y Acad Sci       Date:  1959-09-17       Impact factor: 5.691

3.  Potentiating action of chlorpromazine and reserpine.

Authors:  B B BRODIE; P A SHORE; S L SILVER
Journal:  Nature       Date:  1955-06-25       Impact factor: 49.962

4.  Pharmacological effects produced by intracerebral injection of drugs in the conscious mouse.

Authors:  T J HALEY; W G MCCORMICK
Journal:  Br J Pharmacol Chemother       Date:  1957-03

5.  A facilitation action of reserpine on the central nervous system.

Authors:  G CHEN; C R ENSOR; B BOHNER
Journal:  Proc Soc Exp Biol Med       Date:  1954-07

6.  Cholinergic and adrenergic inhibition in the rat cerebral cortex.

Authors:  J L Malcolm; P Saraiva; P J Spear
Journal:  Int J Neuropharmacol       Date:  1967-11

7.  New possibilities for adrenergic modulation of ganglionic transmission.

Authors:  K A Norberg; F Sjöqvist
Journal:  Pharmacol Rev       Date:  1966-03       Impact factor: 25.468

8.  Central adrenergic synapses.

Authors:  G C Salmoiraghi
Journal:  Pharmacol Rev       Date:  1966-03       Impact factor: 25.468

9.  The effect of reserpine, alpha-methyl-m-tyrosine, prenylamine, and guanethidine on metrazol-convulsions and the brain monoamine level in mice.

Authors:  A K Pfeifer; E Galambos
Journal:  Arch Int Pharmacodyn Ther       Date:  1967-01

10.  Temperature changes produced by the injection of catecholamines and 5-hydroxytryptamine into the cerebral ventricles of the conscious mouse.

Authors:  R T Brittain; S L Handley
Journal:  J Physiol       Date:  1967-10       Impact factor: 5.182
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