Literature DB >> 1364128

The multiple drug resistance gene, MDR1: expression at the protein and RNA levels.

Y Q Li1, V Gopal, P Kadam, S Files, H Preisler.   

Abstract

A comparison of three different approaches to detect MDR1 expression in myeloid leukemia cells was undertaken. With respect to the 4 different antibodies studied, a high proportion of false positive reactions were detected. Substantial discordance between MDR1 expression as indicated by Northern blot analysis, PCR, and immunohistochemistry was found. These findings complicate the clinical interpretation of data derived from these methods.

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Year:  1992        PMID： 1364128     DOI： 10.1007/bf02989647

Source DB:  PubMed          Journal:  Med Oncol Tumor Pharmacother        ISSN： 0736-0118


  15 in total

1.  Genomic sequencing.

Authors:  G M Church; W Gilbert
Journal:  Proc Natl Acad Sci U S A       Date:  1984-04       Impact factor: 11.205

2.  A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity.

Authors:  A P Feinberg; B Vogelstein
Journal:  Anal Biochem       Date:  1983-07-01       Impact factor: 3.365

3.  MDR1 transcript levels as an indication of resistant disease in acute myelogenous leukaemia.

Authors:  H Sato; H Preisler; R Day; A Raza; R Larson; G Browman; J Goldberg; R Vogler; H Grunwald; A Gottlieb
Journal:  Br J Haematol       Date:  1990-07       Impact factor: 6.998

4.  Proposals for the classification of the acute leukaemias. French-American-British (FAB) co-operative group.

Authors:  J M Bennett; D Catovsky; M T Daniel; G Flandrin; D A Galton; H R Gralnick; C Sultan
Journal:  Br J Haematol       Date:  1976-08       Impact factor: 6.998

5.  Isolation of human mdr DNA sequences amplified in multidrug-resistant KB carcinoma cells.

Authors:  I B Roninson; J E Chin; K G Choi; P Gros; D E Housman; A Fojo; D W Shen; M M Gottesman; I Pastan
Journal:  Proc Natl Acad Sci U S A       Date:  1986-06       Impact factor: 11.205

6.  Quantitative analysis of MDR1 (multidrug resistance) gene expression in human tumors by polymerase chain reaction.

Authors:  K E Noonan; C Beck; T A Holzmayer; J E Chin; J S Wunder; I L Andrulis; A F Gazdar; C L Willman; B Griffith; D D Von Hoff; I B Roninson
Journal:  Proc Natl Acad Sci U S A       Date:  1990-09       Impact factor: 11.205

7.  Expression of mdr1 and mdr3 multidrug-resistance genes in human acute and chronic leukemias and association with stimulation of drug accumulation by cyclosporine.

Authors:  H Herweijer; P Sonneveld; F Baas; K Nooter
Journal:  J Natl Cancer Inst       Date:  1990-07-04       Impact factor: 13.506

8.  Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells.

Authors:  C J Chen; J E Chin; K Ueda; D P Clark; I Pastan; M M Gottesman; I B Roninson
Journal:  Cell       Date:  1986-11-07       Impact factor: 41.582

9.  Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease.

Authors:  J M Chirgwin; A E Przybyla; R J MacDonald; W J Rutter
Journal:  Biochemistry       Date:  1979-11-27       Impact factor: 3.162

10.  The human mdr3 gene encodes a novel P-glycoprotein homologue and gives rise to alternatively spliced mRNAs in liver.

Authors:  A M Van der Bliek; F Baas; T Ten Houte de Lange; P M Kooiman; T Van der Velde-Koerts; P Borst
Journal:  EMBO J       Date:  1987-11       Impact factor: 11.598
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