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Literature DB >> 1362221

Association between schizophrenia and homozygosity at the dopamine D3 receptor gene.

M A Crocq¹, R Mant, P Asherson, J Williams, Y Hode, A Mayerova, D Collier, L Lannfelt, P Sokoloff, J C Schwartz.

Abstract

Disturbances in dopamine neurotransmission have been postulated to underlie schizophrenia. We report data from two independent studies of a BalI polymorphism in the dopamine D3 receptor gene in patients with schizophrenia. In both studies, more patients than controls were homozygous (p = 0.005, p = 0.008). When pooled data were analysed, this difference was highly significant (p = 0.0001) with a relative risk of schizophrenia in homozygotes of 2.61 (95% confidence intervals 1.60-4.26).

Entities: Chemical Disease Gene Mutation Species

Mesh：

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Year: 1992 PMID： 1362221 PMCID： PMC1016201 DOI： 10.1136/jmg.29.12.858

Source DB: PubMed Journal: J Med Genet ISSN： 0022-2593 Impact factor: 6.318

6 in total

1. On estimating the relation between blood group and disease.

Authors: B WOOLF
Journal: Ann Hum Genet Date: 1955-06 Impact factor: 1.670

Review 2. Will schizophrenia become a graveyard for molecular geneticists?

Authors: M J Owen
Journal: Psychol Med Date: 1992-05 Impact factor: 7.723

3. Cloning of the gene for a human dopamine D5 receptor with higher affinity for dopamine than D1.

Authors: R K Sunahara; H C Guan; B F O'Dowd; P Seeman; L G Laurier; G Ng; S R George; J Torchia; H H Van Tol; H B Niznik
Journal: Nature Date: 1991-04-18 Impact factor: 49.962

4. Molecular cloning and characterization of a novel dopamine receptor (D3) as a target for neuroleptics.

Authors: P Sokoloff; B Giros; M P Martres; M L Bouthenet; J C Schwartz
Journal: Nature Date: 1990-09-13 Impact factor: 49.962

Review 5. The current status of the dopamine hypothesis of schizophrenia.

Authors: A Carlsson
Journal: Neuropsychopharmacology Date: 1988-09 Impact factor: 7.853

6. Cloning of the gene for a human dopamine D4 receptor with high affinity for the antipsychotic clozapine.

Authors: H H Van Tol; J R Bunzow; H C Guan; R K Sunahara; P Seeman; H B Niznik; O Civelli
Journal: Nature Date: 1991-04-18 Impact factor: 49.962

6 in total

39 in total

Review 1. Candidate-gene association studies of schizophrenia.

Authors: M C O'Donovan; M J Owen
Journal: Am J Hum Genet Date: 1999-09 Impact factor: 11.025

Review 2. Genetic analyses of schizophrenia.

Authors: C N Pato; K M Schindler; M T Pato
Journal: Curr Psychiatry Rep Date: 2000-04 Impact factor: 5.285

Association between schizophrenia and homozygosity at the dopamine D3 receptor gene.

1. On estimating the relation between blood group and disease.

Review 2. Will schizophrenia become a graveyard for molecular geneticists?

3. Cloning of the gene for a human dopamine D5 receptor with higher affinity for dopamine than D1.

4. Molecular cloning and characterization of a novel dopamine receptor (D3) as a target for neuroleptics.

Review 5. The current status of the dopamine hypothesis of schizophrenia.

6. Cloning of the gene for a human dopamine D4 receptor with high affinity for the antipsychotic clozapine.

Review 1. Candidate-gene association studies of schizophrenia.

Review 2. Genetic analyses of schizophrenia.

Review 3. Molecular genetics of schizophrenia: a critical review.

4. Candidate gene polymorphisms among North Indians and their association with schizophrenia in a case-control study.

5. The dopamine D3 receptor gene and posttraumatic stress disorder.

6. A search for association between schizophrenia and dopamine-related alleles.

Review 7. G protein-coupled receptors in major psychiatric disorders.

Review 8. Drug treatment of resistant schizophrenia. Limitations and recommendations.

Review 9. History of the Concept of Disconnectivity in Schizophrenia.

10. Allelic association between a Ser-9-Gly polymorphism in the dopamine D3 receptor gene and schizophrenia.