Literature DB >> 136099

The influence of platelet aggregation inhibitors on metastasis formation in mice (3LL).

P Hilgard, H Heller, C G Schmidt.   

Abstract

Platelets were suggested to play a specific role in the haematogenous spread of experimental tumours. To test this hypothesis mice were treated with various inhibitors or platelet function (acetyl-salicylic acid, RA 233, bencyclan-, cyproheptadine). The effect of treatment on the development of lung colonies after i.v. tumour cell injection as well as on the formation of spontaneous metastases from the solid Lewis-lung carcinoma was evaluated. A significant increase of lung colonies after pretreatment with the platelet aggregation inhibitors was found. The effect of long term treatment on spontaneous metastasis formation gave equivocal results. The present investigations do not support the importance of the integrity of platelet function as a prerequisite for metastasis formation.

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Year:  1976        PMID： 136099     DOI： 10.1007/bf00286943

Source DB:  PubMed          Journal:  Z Krebsforsch Klin Onkol Cancer Res Clin Oncol        ISSN： 0084-5353


  18 in total

1.  Electron microscopic observations on formation of pulmonary metastases.

Authors:  W F Sindelar; T S Tralka; A S Ketcham
Journal:  J Surg Res       Date:  1975-02       Impact factor: 2.192

2.  Reduction of thrombus formation on dialyser membranes by aspirin and RA 233.

Authors:  R M Lindsay; D Ferguson; C R Prentice; J A Burton; G P McNicol
Journal:  Lancet       Date:  1972-12-16       Impact factor: 79.321

3.  Aspirin and tumour metastasis.

Authors:  S Wood; P Hilgard
Journal:  Lancet       Date:  1972-12-30       Impact factor: 79.321

4.  The inhibition of thrombocyte adhesion by bencyclane: experimental and clinical results.

Authors:  M Martin; G Schäfer; U Martin; H Juraschek; W Knüll
Journal:  Thromb Res       Date:  1974-06       Impact factor: 3.944

5.  Microangiopathic haemolytic anaemia and experimental tumour-cell emboli.

Authors:  P Hilgard; E C Gordon-Smith
Journal:  Br J Haematol       Date:  1974-04       Impact factor: 6.998

6.  Antimetastatic effects associated with platelet reduction.

Authors:  G J Gasic; T B Gasic; C C Stewart
Journal:  Proc Natl Acad Sci U S A       Date:  1968-09       Impact factor: 11.205

7.  The effects of an antimetastatic agent, (plus or minus)-1,2-bis(3,5-dioxopiperazin-1-yl)propane (ICRF 159), on platelet behavior.

Authors:  A Atherton; D Busfield; K Hellman
Journal:  Cancer Res       Date:  1975-04       Impact factor: 12.701

8.  Platelet-tumor-cell interactions in mice. The role of platelets in the spread of malignant disease.

Authors:  G J Gasic; T B Gasic; N Galanti; T Johnson; S Murphy
Journal:  Int J Cancer       Date:  1973-05       Impact factor: 7.396

9.  Relation of microcirculatory thrombosis to thrombus in the proximal coronary artery: effect of aspirin, dipyridamole, and thrombolysis.

Authors:  C B Moschos; K Lahiri; M Lyons; A B Weisse; H A Oldewurtel; T J Regan
Journal:  Am Heart J       Date:  1973-07       Impact factor: 4.749

10.  The role of blood platelets in experimental metastases.

Authors:  P Hilgard
Journal:  Br J Cancer       Date:  1973-11       Impact factor: 7.640
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  18 in total

Review 1.  Non-tissue factor procoagulants in cancer cells.

Authors:  S G Gordon; M Chelladurai
Journal:  Cancer Metastasis Rev       Date:  1992-11       Impact factor: 9.264

2.  The role of calcium channels and serotonin (5-HT2) receptors for tumour cell lodgement in the liver.

Authors:  G Skolnik; U Bagge; G Blomqvist; L Djärv; H Ahlman
Journal:  Clin Exp Metastasis       Date:  1989 Mar-Apr       Impact factor: 5.150

3.  Investigation of the biological effects of anti-cell adhesive synthetic peptides that inhibit experimental metastasis of B16-F10 murine melanoma cells.

Authors:  M J Humphries; K M Yamada; K Olden
Journal:  J Clin Invest       Date:  1988-03       Impact factor: 14.808

4.  Aggregation of activated platelets with Walker 256 carcinoma cells.

Authors:  W Paschen; H Patscheke; P Wörner
Journal:  Blut       Date:  1979-01-22

Review 5.  Role of plasma, platelets, and endothelial cells in tumor metastasis.

Authors:  G J Gasic
Journal:  Cancer Metastasis Rev       Date:  1984       Impact factor: 9.264

6.  Effect of verapamil on doxorubicin activity and pharmacokinetics in mice bearing resistant and sensitive solid tumors.

Authors:  F Formelli; L Cleris; R Carsana
Journal:  Cancer Chemother Pharmacol       Date:  1988       Impact factor: 3.333

7.  Failure of orally administered RA233 to influence B16 melanoma growth or metastasis.

Authors:  C W Stackpole; D M Fornabaio; A L Alterman
Journal:  Clin Exp Metastasis       Date:  1987 Apr-Jun       Impact factor: 5.150

8.  Effect of RA233 alone and combined with radiation on experimental tumour metastasis. Part 1.

Authors:  X T Li; K Hellmann
Journal:  Clin Exp Metastasis       Date:  1983 Jan-Mar       Impact factor: 5.150

9.  Antitumor effect of RA233 alone and combined with radiotherapy.

Authors:  X T Li; K Hellmann
Journal:  Clin Exp Metastasis       Date:  1983 Apr-Jun       Impact factor: 5.150

10.  Effects of RA 233 treatment on the adhesive, invasive and metastatic properties of 13762NF rat mammary tumor cells.

Authors:  R B Lichtner; L J Erkell; V Schirrmacher; G L Nicolson
Journal:  Clin Exp Metastasis       Date:  1989 Mar-Apr       Impact factor: 5.150
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