Literature DB >> 1357848

Interleukin-6 in normal skin and psoriasis.

A Castells-Rodellas1, J V Castell, A Ramirez-Bosca, J F Nicolas, F Valcuende-Cavero, J Thivolet.   

Abstract

Interleukin-6 (IL-6 or BSF-2/IFN beta 2) is a component of normal human skin. IL-6 was immunologically detected in basal keratinocytes, endothelial cells and in a number of mononucleated cells and fibroblasts in normal skin and sudoriparous ducts. In psoriasis, intense labelling of the cytoplasm in the vicinity of keratinocyte membranes was detected in all epidermal layers and other skin appendages. The fact that this interleukin acts synergistically with respect to IL-1 and Tumour Necrosis Factor (TNF) strengthens the hypothesis whereby IL-6 may contribute via its receptor action to EGF function in modulating cell hyper-proliferation in psoriasis.

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Year:  1992        PMID： 1357848     DOI： 102340/0001555572165168

Source DB:  PubMed          Journal:  Acta Derm Venereol        ISSN： 0001-5555            Impact factor:   4.437


  19 in total

1.  IL-6 regulates neutrophil microabscess formation in IL-17A-driven psoriasiform lesions.

Authors:  Andrew L Croxford; Susanne Karbach; Florian C Kurschus; Simone Wörtge; Alexei Nikolaev; Nir Yogev; Sabrina Klebow; Rebecca Schüler; Sonja Reissig; Carolin Piotrowski; Elke Brylla; Ingo Bechmann; Jürgen Scheller; Stefan Rose-John; F Thomas Wunderlich; Thomas Münzel; Esther von Stebut; Ari Waisman
Journal:  J Invest Dermatol       Date:  2013-09-25       Impact factor: 8.551

2.  Interleukin 6 receptors on human outer root sheath cells and interfollicular epidermal keratinocytes in vitro: density-induced down regulation (DIDR) of receptors.

Authors:  E R Waelti; S P Inaebnit; U Weismann; A Limat; T Hunziker
Journal:  In Vitro Cell Dev Biol Anim       Date:  1996-05       Impact factor: 2.416

3.  Detection of elevated levels of IL-4, IL-6, and IL-10 in blister fluid of bullous pemphigoid.

Authors:  E Schmidt; B Bastian; R Dummer; H P Tony; E B Bröcker; D Zillikens
Journal:  Arch Dermatol Res       Date:  1996-06       Impact factor: 3.017

Review 4.  Regulation generation: the suppressive functions of human regulatory T cells.

Authors:  Wendy A Goodman; Kevin D Cooper; Thomas S McCormick
Journal:  Crit Rev Immunol       Date:  2012       Impact factor: 2.214

5.  Induction of Alternative Proinflammatory Cytokines Accounts for Sustained Psoriasiform Skin Inflammation in IL-17C+IL-6KO Mice.

Authors:  Yi Fritz; Philip A Klenotic; William R Swindell; Zhi Qiang Yin; Sarah G Groft; Li Zhang; Jaymie Baliwag; Maya I Camhi; Doina Diaconu; Andrew B Young; Alexander M Foster; Andrew Johnston; Johann E Gudjonsson; Thomas S McCormick; Nicole L Ward
Journal:  J Invest Dermatol       Date:  2016-10-27       Impact factor: 8.551

6.  Lithium and psoriasis: cytokine modulation of cultured lymphocytes and psoriatic keratinocytes by lithium.

Authors:  H M Ockenfels; S N Wagner; C Keim-Maas; R Funk; G Nussbaum; M Goos
Journal:  Arch Dermatol Res       Date:  1996-04       Impact factor: 3.017

7.  Immunohistochemical localization of IL-1 alpha-, IL-1 beta-, IL-6- and TNF-alpha-like immunoreactivities in human apocrine glands.

Authors:  A A Ahmed; K Nordlind; M Schultzberg; S Lidén
Journal:  Arch Dermatol Res       Date:  1995       Impact factor: 3.017

Review 8.  Modulatory effects of selenium and strontium salts on keratinocyte-derived inflammatory cytokines.

Authors:  P Celerier; A Richard; P Litoux; B Dreno
Journal:  Arch Dermatol Res       Date:  1995       Impact factor: 3.017

9.  Defective immune response and severe skin damage following UVB irradiation in interleukin-6-deficient mice.

Authors:  N Nishimura; C Tohyama; M Satoh; H Nishimura; V E Reeve
Journal:  Immunology       Date:  1999-05       Impact factor: 7.397

10.  Interleukin 6 regulates psoriasiform inflammation-associated thrombosis.

Authors:  Yunmei Wang; Jackelyn B Golden; Yi Fritz; Xiufen Zhang; Doina Diaconu; Maya I Camhi; Huiyun Gao; Sean M Dawes; Xianying Xing; Santhi K Ganesh; Johann E Gudjonsson; Daniel I Simon; Thomas S McCormick; Nicole L Ward
Journal:  JCI Insight       Date:  2016-12-08
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