Literature DB >> 1354264

Disodium (R,R)-5-[2-[[2-(3-chlorophenyl)-2-hydroxyethyl]-amino] propyl]-1,3-benzodioxole-2,2-dicarboxylate (CL 316,243). A potent beta-adrenergic agonist virtually specific for beta 3 receptors. A promising antidiabetic and antiobesity agent.

J D Bloom1, M D Dutia, B D Johnson, A Wissner, M G Burns, E E Largis, J A Dolan, T H Claus.   

Abstract

Mesh：

Substances：

Year:  1992        PMID： 1354264     DOI： 10.1021/jm00094a025

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


× No keyword cloud information.
  57 in total

Review 1.  Enzymatic synthesis of chiral intermediates for pharmaceuticals.

Authors:  Ramesh Patel; Ronald Hanson; Animesh Goswami; Venkata Nanduri; Amit Banerjee; Mary-Jo Donovan; Steven Goldberg; Robert Johnston; David Brzozowski; Thomas Tully; Jeffrey Howell; Dana Cazzulino; Rapheal Ko
Journal:  J Ind Microbiol Biotechnol       Date:  2003-03-25       Impact factor: 3.346

2.  G(s)alpha deficiency in adipose tissue leads to a lean phenotype with divergent effects on cold tolerance and diet-induced thermogenesis.

Authors:  Min Chen; Hui Chen; Annie Nguyen; Divakar Gupta; Jie Wang; Edwin W Lai; Karel Pacak; Oksana Gavrilova; Michael J Quon; Lee S Weinstein
Journal:  Cell Metab       Date:  2010-04-07       Impact factor: 27.287

3.  Direct demonstration of beta1- and evidence against beta2- and beta3-adrenoceptors, in smooth muscle cells of rat small mesenteric arteries.

Authors:  Ana M Briones; Craig J Daly; Francesc Jimenez-Altayo; Sonia Martinez-Revelles; Jose M Gonzalez; John C McGrath; Elisabet Vila
Journal:  Br J Pharmacol       Date:  2005-11       Impact factor: 8.739

4.  A creatine-driven substrate cycle enhances energy expenditure and thermogenesis in beige fat.

Authors:  Lawrence Kazak; Edward T Chouchani; Mark P Jedrychowski; Brian K Erickson; Kosaku Shinoda; Paul Cohen; Ramalingam Vetrivelan; Gina Z Lu; Dina Laznik-Bogoslavski; Sebastian C Hasenfuss; Shingo Kajimura; Steve P Gygi; Bruce M Spiegelman
Journal:  Cell       Date:  2015-10-22       Impact factor: 41.582

5.  Evidence for fatty acids mediating CL 316,243-induced reductions in blood glucose in mice.

Authors:  Rebecca E K MacPherson; Laura Castellani; Marie-Soleil Beaudoin; David C Wright
Journal:  Am J Physiol Endocrinol Metab       Date:  2014-08-05       Impact factor: 4.310

6.  Effects on energy utilization of a beta3-adrenergic agonist in rats fed on a cafeteria diet.

Authors:  B Berraondo; A Bonafonte; M P Fernandez-Otero; J A Martinez
Journal:  Eat Weight Disord       Date:  1997-09       Impact factor: 4.652

7.  Tissue functions mediated by beta(3)-adrenoceptors-findings and challenges.

Authors:  Martin C Michel; Peter Ochodnicky; Roger J Summers
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2010-06-03       Impact factor: 3.000

8.  Stimulated release of a hyperpolarizing factor (ADHF) from mesenteric artery perivascular adipose tissue: involvement of myocyte BKCa channels and adiponectin.

Authors:  A H Weston; I Egner; Y Dong; E L Porter; A M Heagerty; G Edwards
Journal:  Br J Pharmacol       Date:  2013-08       Impact factor: 8.739

9.  Comparison of the profiles of agonists as stimulants of the beta 3-adrenoceptor in vitro with their gastroprotective effects in the conscious rat.

Authors:  A K Bahl; N M Clayton; J Coates; D P Martin; I G Oakley; P Strong; M A Trevethick
Journal:  Br J Pharmacol       Date:  1996-02       Impact factor: 8.739

10.  Insulin-sensitizing therapy attenuates type 2 diabetes-mediated mammary tumor progression.

Authors:  Yvonne Fierz; Ruslan Novosyadlyy; Archana Vijayakumar; Shoshana Yakar; Derek LeRoith
Journal:  Diabetes       Date:  2009-12-03       Impact factor: 9.461
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.