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Literature DB >> 12687489

Enzymatic synthesis of chiral intermediates for pharmaceuticals.

Ramesh Patel¹, Ronald Hanson, Animesh Goswami, Venkata Nanduri, Amit Banerjee, Mary-Jo Donovan, Steven Goldberg, Robert Johnston, David Brzozowski, Thomas Tully, Jeffrey Howell, Dana Cazzulino, Rapheal Ko.

Abstract

There has been an increasing awareness of the enormous potential of microorganisms and enzymes for the transformation of synthetic chemicals with high chemo-, regio- and enatioselective manner. Chiral intermediates are in high demand by pharmaceutical industries for the preparation bulk drug substances. In this review article, microbial/enzymatic processes for the synthesis of chiral intermediates for antihypertensive drugs, melatonin receptor agonists, and beta3-receptor receptor agonists are described.

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Year: 2003 PMID： 12687489 DOI： 10.1007/s10295-003-0032-6

Source DB: PubMed Journal: J Ind Microbiol Biotechnol ISSN： 1367-5435 Impact factor: 3.346

15 in total

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Authors: A Zaks
Journal: Curr Opin Chem Biol Date: 2001-04 Impact factor: 8.822

Review 2. Biocatalysis for pharmaceuticals--status and prospects for a key technology.

Authors: B C Buckland; D K Robinson; M Chartrain
Journal: Metab Eng Date: 2000-01 Impact factor: 9.783

3. FDA's policy statement for the development of new stereoisomeric drugs.

Authors:
Journal: Chirality Date: 1992 Impact factor: 2.437

4. Disodium (R,R)-5-[2-[[2-(3-chlorophenyl)-2-hydroxyethyl]-amino] propyl]-1,3-benzodioxole-2,2-dicarboxylate (CL 316,243). A potent beta-adrenergic agonist virtually specific for beta 3 receptors. A promising antidiabetic and antiobesity agent.

Authors: J D Bloom; M D Dutia; B D Johnson; A Wissner; M G Burns; E E Largis; J A Dolan; T H Claus
Journal: J Med Chem Date: 1992-08-07 Impact factor: 7.446

5. Recent progress in enzymatic resolution and desymmetrization of pharmaceuticals and their intermediates.

Authors: J A Pesti; R Dicosimo
Journal: Curr Opin Drug Discov Devel Date: 2000-11

6. Enzymatic synthesis of L-6-hydroxynorleucine.

Authors: R L Hanson; M D Schwinden; A Banerjee; D B Brzozowski; B C Chen; B P Patel; C G McNamee; G A Kodersha; D R Kronenthal; R N Patel; L J Szarka
Journal: Bioorg Med Chem Date: 1999-10 Impact factor: 3.641

7. Chemical synthesis of allysine ethylene acetal and conversion in situ into 1-piperideine-6-carboxylic acid: key intermediate of the alpha-aminoadipic acid for beta-lactam antibiotics biosynthesis.

Authors: A Rumbero; J F Martín; M A Lumbreras; P Liras; C Esmahan
Journal: Bioorg Med Chem Date: 1995-09 Impact factor: 3.641

Enzymatic synthesis of chiral intermediates for pharmaceuticals.

Review 1. Industrial biocatalysis.

Review 2. Biocatalysis for pharmaceuticals--status and prospects for a key technology.

3. FDA's policy statement for the development of new stereoisomeric drugs.

4. Disodium (R,R)-5-[2-[[2-(3-chlorophenyl)-2-hydroxyethyl]-amino] propyl]-1,3-benzodioxole-2,2-dicarboxylate (CL 316,243). A potent beta-adrenergic agonist virtually specific for beta 3 receptors. A promising antidiabetic and antiobesity agent.

5. Recent progress in enzymatic resolution and desymmetrization of pharmaceuticals and their intermediates.

6. Enzymatic synthesis of L-6-hydroxynorleucine.

7. Chemical synthesis of allysine ethylene acetal and conversion in situ into 1-piperideine-6-carboxylic acid: key intermediate of the alpha-aminoadipic acid for beta-lactam antibiotics biosynthesis.

8. NAD-linked formate dehydrogenase from methanol-grown Pichia pastoris NRRL-Y-7556.

Review 9. Enzymatic synthesis of chiral intermediates for Omapatrilat, an antihypertensive drug.

10. Synthesis of allysine ethylene acetal using phenylalanine dehydrogenase from Thermoactinomyces intermedius.

Review 1. Biocatalytic Reduction Reactions from a Chemist's Perspective.