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Literature DB >> 13536274

A quantitative method for the assay of inhibitors of acid gastric secretion in the rat.

Abstract

Assays of inhibitors of gastric secretion are described by a method of recording continuously acid gastric secretion in the rat. A number of doses of inhibitor comprising several assay blocks can be administered in one preparation and complete assays with known fiducial limits performed with only two rats. Assays were carried out with vasopressin against secretion induced by histamine, and with atropine, methanthelinium and atropine methylnitrate against secretion induced by methacholine.

Entities: Chemical Gene Species

Keywords: GASTRIC JUICE

Mesh：

Substances：

Year: 1958 PMID： 13536274 PMCID： PMC1481717 DOI： 10.1111/j.1476-5381.1958.tb00205.x

Source DB: PubMed Journal: Br J Pharmacol Chemother ISSN： 0366-0826

7 in total

1. Continuous recording of acid gastric secretion in the rat.

Authors: M N GHOSH; H O SCHILD
Journal: Br J Pharmacol Chemother Date: 1958-03

2. Experimental design for bioassay of a material inducing strong tachyphylactic effect (anaphylatoxin).

Authors: E M ROCHA SILVA; A M ROTHSCHILD
Journal: Br J Pharmacol Chemother Date: 1956-09

3. Inhibition of gastric secretion in rats by some quaternary derivatives of atropine.

Authors: S M SHEA
Journal: Br J Pharmacol Chemother Date: 1956-06

4. Pharmacology of pamine bromide.

Authors: F E VISSCHER; P H SEAY; A P TAZELAAR; W VELDKAMP; M J VANDER BROOK
Journal: J Pharmacol Exp Ther Date: 1954-02 Impact factor: 4.030

5. A comparison of the effectiveness of banthine and atropine in depressing gastric acid secretion in man and the dog.

Authors: F B BENJAMIN; C E ROSIERE; M I GROSSMAN
Journal: Gastroenterology Date: 1950-08 Impact factor: 22.682

6. Comparison of the effects of methantheline bromide (banthine) and atropine on the secretory responses of vagally innervated and vagally denervated gastric pouches.

Authors: C F CODE; N C HIGHTOWER; G A HALLENBECK
Journal: Gastroenterology Date: 1951-10 Impact factor: 22.682

7. A comparison of the peripheral parasympatholytic and autonomic ganglion blocking activities of methantheline (banthine) and propantheline (probanthine) with atropine and hexamethonium.

Authors: E A JOHNSON; D R WOOD
Journal: Br J Pharmacol Chemother Date: 1954-06

7 in total

3 in total