Literature DB >> 7009622

Epidermal growth factor inhibits cytoskeleton-related changes in the surface of parietal cells.

A González, J Garrido, J D Vial.   

Abstract

The effect of epidermal growth factor (EGF) on gastric acid secretion was correlated with the morphological changes of the apical pole of rat parietal cells studied by transmission electron microscopy. Gastric acid secretion was stimulated by histamine, carbachol, pentagastrin, and insulin-induced hypoglycemia, and estimated by continuous recording of pH variations of gastric luminal perfusate. EGF inhibits acid secretion in these conditions. The action of the hormone also results in the arrest or reversal of the changes in shape undergone by parietal cells as they go into secretion. In view of the evidence involving cytoskeletal elements in the generation of these structural alterations, our observations suggest that the action of EGF on gastric acid secretion may be a consequence of a general effect of this hormone on cytoskeletal function.

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Year:  1981        PMID： 7009622      PMCID： PMC2111733          DOI： 10.1083/jcb.88.1.108

Source DB:  PubMed          Journal:  J Cell Biol        ISSN： 0021-9525            Impact factor:   10.539


  26 in total

1.  Isolation and structure of urogastrone and its relationship to epidermal growth factor.

Authors:  H Gregory
Journal:  Nature       Date:  1975-09-25       Impact factor: 49.962

2.  The inhibition of gastric acid secretion by epidermal growth factor.

Authors:  J M Bower; R Camble; H Gregory; E L Gerring; I R Willshire
Journal:  Experientia       Date:  1975-07-15

3.  Cellular localization of gastric inhibitory polypeptide in the duodenum and jejunum.

Authors:  J M Polak; S R Bloom; M Kuzio; J C Brown; A G Pearse
Journal:  Gut       Date:  1973-04       Impact factor: 23.059

4.  Inhibition of histamine-, pentagastrin-, and insulin-stimulated canine gastric secretion by pure "gastric inhibitory polypeptide".

Authors:  R A Pederson; J C Brown
Journal:  Gastroenterology       Date:  1972-03       Impact factor: 22.682

5.  Epidermal growth factor: receptors in human fibroblasts and modulation of action by cholera toxin.

Authors:  M D Hollenberg; P Cuatrecasas
Journal:  Proc Natl Acad Sci U S A       Date:  1973-10       Impact factor: 11.205

6.  Epidermal growth factor. Characteristics of specific binding in membranes from liver, placenta, and other target tissues.

Authors:  E O'Keefe; M D Hollenberg; P Cuatrecasas
Journal:  Arch Biochem Biophys       Date:  1974-10       Impact factor: 4.013

7.  Definition and antagonism of histamine H 2 -receptors.

Authors:  J W Black; W A Duncan; C J Durant; C R Ganellin; E M Parsons
Journal:  Nature       Date:  1972-04-21       Impact factor: 49.962

8.  Proceedings: Initial observations on the inhibitory action of urogastrone on gastric secretory responses in man.

Authors:  I E Gillespie; J B Elder; P C Ganguli; H Gregory; L Gerring
Journal:  Gut       Date:  1974-04       Impact factor: 23.059

9.  125I-labeled human epidermal growth factor. Binding, internalization, and degradation in human fibroblasts.

Authors:  G Carpenter; S Cohen
Journal:  J Cell Biol       Date:  1976-10       Impact factor: 10.539

10.  Studies on the depletion and accumulation of microvilli and changes in the tubulovesicular compartment of mouse parietal cells in relation to gastric acid secretion.

Authors:  S Ito; G C Schofield
Journal:  J Cell Biol       Date:  1974-11       Impact factor: 10.539
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  10 in total

1.  Cytokine effects on pepsinogen secretion from human peptic cells.

Authors:  M T Serrano; A I Lanas; S Lorente; R Sáinz
Journal:  Gut       Date:  1997-01       Impact factor: 23.059

2.  Characterization of epidermal growth factor receptors on plasma membranes isolated from rat gastric mucosa.

Authors:  R Hori; H Nomura; S Iwakawa; K Okumura
Journal:  Pharm Res       Date:  1990-06       Impact factor: 4.200

3.  Inhibition of acid formation by epidermal growth factor in the isolated rabbit gastric glands.

Authors:  A Dembiński; D Drozdowicz; H Gregory; S J Konturek; Z Warzecha
Journal:  J Physiol       Date:  1986-09       Impact factor: 5.182

4.  Immunoreactivities for epidermal growth factor (EGF) and for EGF receptors in rats with gastric ulcers.

Authors:  H Lee; H A Hansson; E Norström; H F Helander
Journal:  Cell Tissue Res       Date:  1991-08       Impact factor: 5.249

5.  Adrenergic effects on exocrine secretion of rat submandibular epidermal growth factor.

Authors:  P S Olsen; P Kirkegaard; S S Poulsen; E Nexø
Journal:  Gut       Date:  1984-11       Impact factor: 23.059

6.  Hormone-induced actin polymerization in rat hepatoma cells and human leucocytes.

Authors:  K M Rao; J M Betschart; M A Virji
Journal:  Biochem J       Date:  1985-09-15       Impact factor: 3.857

7.  Transforming growth factor alpha inhibits secretion of gastric acid.

Authors:  J A Rhodes; J P Tam; U Finke; M Saunders; J Bernanke; W Silen; R A Murphy
Journal:  Proc Natl Acad Sci U S A       Date:  1986-06       Impact factor: 11.205

8.  Localization of transforming growth factor alpha and its receptor in gastric mucosal cells. Implications for a regulatory role in acid secretion and mucosal renewal.

Authors:  R D Beauchamp; J A Barnard; C M McCutchen; J A Cherner; R J Coffey
Journal:  J Clin Invest       Date:  1989-09       Impact factor: 14.808

9.  Membrane-cytoskeleton dynamics in rat parietal cells: mobilization of actin and spectrin upon stimulation of gastric acid secretion.

Authors:  F Mercier; H Reggio; G Devilliers; D Bataille; P Mangeat
Journal:  J Cell Biol       Date:  1989-02       Impact factor: 10.539

10.  Quantitative subcellular study of apical pole membranes from chicken oxyntic cells in resting and HCl secretory state.

Authors:  C S Koenig; M Dabiké; M Bronfman
Journal:  J Cell Biol       Date:  1987-12       Impact factor: 10.539
  10 in total

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