Literature DB >> 13523145

Some pharmacological properties of murexine (urocanoylcholine).

M J KEYL, V P WHITTAKER.   

Abstract

Murexine (urocanoylcholine, [2-beta-imidazol-4(5)-ylacryloyloxyethyl] trimethylammonium bromide) has been shown to possess ganglion stimulating and neuromuscular blocking actions in cat, dog and rat. The blockade has been shown to be of the depolarizing type both on the basis of the resemblance of the pharmacological properties of the substance to that of known depolarizing blocking agents, and also directly by recording the depolarization produced in the endplate region of the gracilis muscle of the rat.

Entities:  

Keywords:  CHOLINE/related compounds; IMIDAZOLES

Mesh：

Substances：

Year:  1958        PMID： 13523145      PMCID： PMC1481681          DOI： 10.1111/j.1476-5381.1958.tb00200.x

Source DB:  PubMed          Journal:  Br J Pharmacol Chemother        ISSN： 0366-0826


  6 in total

1.  Interrelationship of murexine, dihydromurexine and human cholinesterases.

Authors:  F F FOLDES; E G ERDOS; N BAART; S P SHANOR
Journal:  Proc Soc Exp Biol Med       Date:  1957-03

2.  Physiologically active choline esters in certain marine gastropods and other invertebrates.

Authors:  M J KEYL; I A MICHAELSON; V P WHITTAKER
Journal:  J Physiol       Date:  1957-12-31       Impact factor: 5.182

3.  The cholinergic activity of tetrakis-(dimethylaminomethyl)-methane tetramethobromide.

Authors:  C J KENSLER; H LANGEMANN; C L ZIRKLE
Journal:  J Pharmacol Exp Ther       Date:  1954-02       Impact factor: 4.030

4.  Depolarization of the motor end-plate by decamethonium and acetylcholine.

Authors:  B D BURNS; W D M PATON
Journal:  J Physiol       Date:  1951-09       Impact factor: 5.182

5.  The enzymatic hydrolysis of imidazoleacryloylcholine (murexine) and imidazolepropionylcholine (dihydromurexine) by various cholinesterases.

Authors:  M E GRELIS; I I TABACHNICK
Journal:  Br J Pharmacol Chemother       Date:  1957-09

6.  The mechanism of action of murexine on neuromuscular transmission in the frog.

Authors:  J P QUILLIAM
Journal:  Br J Pharmacol Chemother       Date:  1957-09
  6 in total
  5 in total

1.  Pharmacological properties of betabeta-di-methyl-acryloylcholine and some other beta-substituted acryloylcholines.

Authors:  B HOLMSTEDT; V P WHITTAKER
Journal:  Br J Pharmacol Chemother       Date:  1958-09

2.  The pharmacological actions of some murexine-like substances.

Authors:  V ERSPAMER; A GLASSER
Journal:  Br J Pharmacol Chemother       Date:  1958-12

Review 3.  Are the Traditional Medical Uses of Muricidae Molluscs Substantiated by Their Pharmacological Properties and Bioactive Compounds?

Authors:  Kirsten Benkendorff; David Rudd; Bijayalakshmi Devi Nongmaithem; Lei Liu; Fiona Young; Vicki Edwards; Cathy Avila; Catherine A Abbott
Journal:  Mar Drugs       Date:  2015-08-18       Impact factor: 5.118

4.  Mass spectrometry imaging reveals new biological roles for choline esters and Tyrian purple precursors in muricid molluscs.

Authors:  David Rudd; Maurizio Ronci; Martin R Johnston; Taryn Guinan; Nicolas H Voelcker; Kirsten Benkendorff
Journal:  Sci Rep       Date:  2015-09-01       Impact factor: 4.379

Review 5.  Natural product research in the Australian marine invertebrate Dicathais orbita.

Authors:  Kirsten Benkendorff
Journal:  Mar Drugs       Date:  2013-04-23       Impact factor: 5.118
  5 in total

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