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Literature DB >> 1352270

Genetic heterogeneity of early-onset familial breast cancer.

H Sobol¹, S Mazoyer, S A Narod, S A Smith, D M Black, P Kerbrat, B Jamot, E Solomon, B A Ponder, D Guerin.

Abstract

A gene for early-onset familial breast cancer has recently been mapped to the chromosome 17q12-23 region. In order to confirm the gene location, we have tested an extensive early-onset breast cancer family with 4 markers in this chromosome region. Linkage was negative with all 4 markers. This study suggests that there is genetic heterogeneity among early-onset breast cancer families.

Entities: Disease

Mesh：

Substances：
Genetic Markers

Year: 1992 PMID： 1352270 DOI： 10.1007/bf00194307

Source DB: PubMed Journal: Hum Genet ISSN： 0340-6717 Impact factor: 4.132

11 in total

1. The NM23 gene maps to human chromosome band 17q22 and shows a restriction fragment length polymorphism with BglII.

Authors: L Varesco; M A Caligo; P Simi; D M Black; V Nardini; L Casarino; M Rocchi; G Ferrara; E Solomon; G Bevilacqua
Journal: Genes Chromosomes Cancer Date: 1992-01 Impact factor: 5.006

2. A simple sequence repeat polymorphism at the human growth hormone locus.

Authors: M H Polymeropoulos; D S Rath; H Xiao; C R Merril
Journal: Nucleic Acids Res Date: 1991-02-11 Impact factor: 16.971

3. Inheritance of human breast cancer: evidence for autosomal dominant transmission in high-risk families.

Authors: B Newman; M A Austin; M Lee; M C King
Journal: Proc Natl Acad Sci U S A Date: 1988-05 Impact factor: 11.205

4. Screening for multiple endocrine neoplasia type 2a with DNA-polymorphism analysis.

Authors: H Sobol; S A Narod; Y Nakamura; A Boneu; C Calmettes; D Chadenas; G Charpentier; J F Chatal; N Delepine; M J Delisle
Journal: N Engl J Med Date: 1989-10-12 Impact factor: 91.245

5. A mapped set of DNA markers for human chromosome 17.

Authors: Y Nakamura; M Lathrop; P O'Connell; M Leppert; D Barker; E Wright; M Skolnick; S Kondoleon; M Litt; J M Lalouel
Journal: Genomics Date: 1988-05 Impact factor: 5.736

6. Familial breast-ovarian cancer locus on chromosome 17q12-q23.

Authors: S A Narod; J Feunteun; H T Lynch; P Watson; T Conway; J Lynch; G M Lenoir
Journal: Lancet Date: 1991-07-13 Impact factor: 79.321

7. Linkage of early-onset familial breast cancer to chromosome 17q21.

Authors: J M Hall; M K Lee; B Newman; J E Morrow; L A Anderson; B Huey; M C King
Journal: Science Date: 1990-12-21 Impact factor: 47.728

8. Strategies for multilocus linkage analysis in humans.

Authors: G M Lathrop; J M Lalouel; C Julier; J Ott
Journal: Proc Natl Acad Sci U S A Date: 1984-06 Impact factor: 11.205

9. The human growth hormone locus: nucleotide sequence, biology, and evolution.

Authors: E Y Chen; Y C Liao; D H Smith; H A Barrera-Saldaña; R E Gelinas; P H Seeburg
Journal: Genomics Date: 1989-05 Impact factor: 5.736

10. Genetic analysis of breast cancer in the cancer and steroid hormone study.

Authors: E B Claus; N Risch; W D Thompson
Journal: Am J Hum Genet Date: 1991-02 Impact factor: 11.025

5 in total

1. Bilateral Breast Cancer in a Patient with a Strong Family History of Cancer: Analysis of p53 Germ Line Mutations.

Authors:
Journal: Breast Cancer Date: 1994-12-30 Impact factor: 4.239

2. Linkage analysis in German breast cancer families with early onset of the disease, using highly polymorphic markers from the chromosome 17q11-q24 region.

Authors: W Zimmermann; E Bender; K Rohde; A Reis; R Wiseman; A Futreal; H Krause; H Prokoph; S Werner; S Scherneck
Journal: Am J Hum Genet Date: 1993-04 Impact factor: 11.025