Literature DB >> 1350656

Localized 1H NMR spectra of glutamate in the human brain.

D L Rothman1, C C Hanstock, O A Petroff, E J Novotny, J W Prichard, R G Shulman.   

Abstract

Localized 1H NMR spectra at TE = 12 ms were obtained from cerebral cortex of human subjects using ISIS with surface suppression. The 2.29-ppm resonance was assigned to C4 glutamate with contributions from C4 glutamine and GABA using in vivo spectral editing and comparison of chemical shift with pure compounds. The measured intensity ratio between the 2.29 resonance and the creatine resonance at 3.03 ppm was in good agreement with the ratio predicted from previously reported measurements of glutamate, glutamine, and GABA concentrations in biopsied human brain tissue.

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Year:  1992        PMID： 1350656     DOI： 10.1002/mrm.1910250110

Source DB:  PubMed          Journal:  Magn Reson Med        ISSN： 0740-3194            Impact factor:   4.668


  9 in total

Review 1.  Measuring human brain GABA in vivo: effects of GABA-transaminase inhibition with vigabatrin.

Authors:  O A Petroff; D L Rothman
Journal:  Mol Neurobiol       Date:  1998-02       Impact factor: 5.590

Review 2.  The 13C isotope and nuclear magnetic resonance: unique tools for the study of brain metabolism.

Authors:  G F Mason; K L Behar; J C Lai
Journal:  Metab Brain Dis       Date:  1996-12       Impact factor: 3.584

3.  Increased detectability of alpha brain glutamate/glutamine in neonatal hypoxic-ischemic encephalopathy.

Authors:  Y Pu; Q F Li; C M Zeng; J Gao; J Qi; D X Luo; S Mahankali; P T Fox; J H Gao
Journal:  AJNR Am J Neuroradiol       Date:  2000-01       Impact factor: 3.825

4.  1H-[13C] NMR measurements of [4-13C]glutamate turnover in human brain.

Authors:  D L Rothman; E J Novotny; G I Shulman; A M Howseman; O A Petroff; G Mason; T Nixon; C C Hanstock; J W Prichard; R G Shulman
Journal:  Proc Natl Acad Sci U S A       Date:  1992-10-15       Impact factor: 11.205

Review 5.  What might be the impact on neurology of the analysis of brain metabolism by in vivo magnetic resonance spectroscopy?

Authors:  J Vion-Dury; D J Meyerhoff; P J Cozzone; M W Weiner
Journal:  J Neurol       Date:  1994-05       Impact factor: 4.849

6.  Bipolar disorder comorbid with alcoholism: a 1H magnetic resonance spectroscopy study.

Authors:  Fabiano G Nery; Jeffrey A Stanley; Hua-Hsuan Chen; John P Hatch; Mark A Nicoletti; E Serap Monkul; Beny Lafer; Jair C Soares
Journal:  J Psychiatr Res       Date:  2009-10-08       Impact factor: 4.791

7.  An in vitro 1H nuclear magnetic resonance study of the temporoparietal cortex of Alzheimer brains.

Authors:  P Mohanakrishnan; A H Fowler; J P Vonsattel; M M Husain; P R Jolles; P Liem; R A Komoroski
Journal:  Exp Brain Res       Date:  1995       Impact factor: 1.972

8.  Localized 1H NMR measurements of gamma-aminobutyric acid in human brain in vivo.

Authors:  D L Rothman; O A Petroff; K L Behar; R H Mattson
Journal:  Proc Natl Acad Sci U S A       Date:  1993-06-15       Impact factor: 11.205

9.  A Novel Biomarker of Neuronal Glutamate Metabolism in Nonhuman Primates Using Localized 1H-Magnetic Resonance Spectroscopy: Development and Effects of BNC375, an α7 Nicotinic Acetylcholine Receptor Positive Allosteric Modulator.

Authors:  Corin O Miller; Liza T Gantert; Stephen F Previs; Ying Chen; Kenneth D Anderson; Justina M Thomas; Gerard Sanacora; Jason M Uslaner; Douglas L Rothman; Graeme F Mason
Journal:  Biol Psychiatry Cogn Neurosci Neuroimaging       Date:  2020-09-29
  9 in total

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