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Literature DB >> 7737396

An in vitro 1H nuclear magnetic resonance study of the temporoparietal cortex of Alzheimer brains.

P Mohanakrishnan¹, A H Fowler, J P Vonsattel, M M Husain, P R Jolles, P Liem, R A Komoroski.

Abstract

The concentrations of selected metabolites in the posterior temporoparietal cortex of 13 Alzheimer's diseased (AD) and four nondemented postmortem brains (of individuals between the ages of 63 and 95) were determined using high-resolution 1H nuclear magnetic resonance (NMR) spectroscopy. The estimates for glutamate and inositol for AD brains did not show any statistically significant difference (P > 0.05) from those for the nondemented brains. The putative neuronal marker N-acetyl aspartate (NAA), creatine, and GABA were decreased in AD brains compared with the nondemented brains. The estimates for creatine, glutamate, and GABA showed significant linear correlations with those of NAA. Creatine, glutamate, GABA, and NAA appeared to be negatively correlated with the neurofibrillary tangles. Our results support a neuronal loss in the posterior temporoparietal cortices of AD brains.

Entities: Chemical Disease

Mesh：

Substances：

Year: 1995 PMID： 7737396 DOI： 10.1007/bf00230654

Source DB: PubMed Journal: Exp Brain Res ISSN： 0014-4819 Impact factor: 1.972

23 in total

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Journal: NMR Biomed Date: 1991-08 Impact factor: 4.044

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Authors: C E Stokes; K R Gillon; J N Hawthorne
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Authors: S L Lowe; D M Bowen; P T Francis; D Neary
Journal: Neuroscience Date: 1990 Impact factor: 3.590

Review 5. GABAergic dysfunction, neural network hyperactivity and memory impairments in human aging and Alzheimer's disease.

Authors: Joan Jiménez-Balado; Teal S Eich
Journal: Semin Cell Dev Biol Date: 2021-02-09 Impact factor: 7.727

5 in total

An in vitro 1H nuclear magnetic resonance study of the temporoparietal cortex of Alzheimer brains.

1. N-acetyl-L-aspartate and other amino acid metabolites in Alzheimer's disease brain: a preliminary proton nuclear magnetic resonance study.

2. The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer's disease.

3. On the N-acetyl methyl resonance in localized 1H NMR spectra of human brain in vivo.

4. Microtubule-associated protein tau (tau) is a major antigenic component of paired helical filaments in Alzheimer disease.

5. High-resolution proton magnetic resonance spectroscopy of rabbit brain: regional metabolite levels and postmortem changes.

Review 6. N-acetyl-L-aspartic acid: a literature review of a compound prominent in 1H-NMR spectroscopic studies of brain.

7. Neurotransmitter-related enzymes and indices of hypoxia in senile dementia and other abiotrophies.

8. Free and total lipid myo-inositol concentrations decrease with age in human brain.

9. Ante mortem cerebral amino acid concentrations indicate selective degeneration of glutamate-enriched neurons in Alzheimer's disease.

10. Oral tetrahydroaminoacridine in long-term treatment of senile dementia, Alzheimer type.

1. Selective reduction of N-acetylaspartate in medial temporal and parietal lobes in AD.

2. ¹H- and ¹³C-NMR spectroscopy of Thy-1-APPSL mice brain extracts indicates metabolic changes in Alzheimer's disease.

Review 3. Magnetic resonance imaging and magnetic resonance spectroscopy in dementias.

Review 4. Towards a Better Understanding of GABAergic Remodeling in Alzheimer's Disease.

Review 5. GABAergic dysfunction, neural network hyperactivity and memory impairments in human aging and Alzheimer's disease.