Literature DB >> 1350635

Partition and distribution coefficients of aryloxypropanolamine beta-adrenoceptor antagonists.

M Recanatini1.   

Abstract

n-Octanol/water partition and distribution coefficients of fifteen beta-blockers have been measured and the relationships between log P (neutral species), log Pi (fully ionized species) and log D7.4 have been examined. A strict correlation exists among these three parameters, suggesting that the ionization exerts similar effects on the partition behaviour of these drugs.

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Year:  1992        PMID： 1350635     DOI： 10.1111/j.2042-7158.1992.tb14369.x

Source DB:  PubMed          Journal:  J Pharm Pharmacol        ISSN： 0022-3573            Impact factor:   3.765


  3 in total

1.  Prediction of Tissue-Plasma Partition Coefficients Using Microsomal Partitioning: Incorporation into Physiologically based Pharmacokinetic Models and Steady-State Volume of Distribution Predictions.

Authors:  Kimberly Holt; Min Ye; Swati Nagar; Ken Korzekwa
Journal:  Drug Metab Dispos       Date:  2019-07-19       Impact factor: 3.922

2.  Mechanisms of liposomes/water partitioning of (p-methylbenzyl)alkylamines.

Authors:  R Fruttero; G Caron; E Fornatto; D Boschi; G Ermondi; A Gasco; P A Carrupt; B Testa
Journal:  Pharm Res       Date:  1998-09       Impact factor: 4.200

3.  Estimation of the octanol-water distribution coefficient of basic compounds by a cationic microemulsion electrokinetic chromatography system.

Authors:  Alejandro Fernández-Pumarega; Belén Martín-Sanz; Susana Amézqueta; Elisabet Fuguet; Martí Rosés
Journal:  ADMET DMPK       Date:  2020-03-04
  3 in total

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