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Literature DB >> 1349742

The murine Hox-2.4 promoter contains a functional octamer motif.

F Zwartkruis¹, T Hoeijmakers, J Deschamps, F Meijlink.

Abstract

Like other HOX genes the murine Hox-2.4 gene is thought to be involved in regional specification along the antero-posterior axis. In addition it has been reported to have oncogenic potential. We studied expression Hox-2.4 in murine EC cells and determined the transcription start site. Studies of DNA-protein interactions in the promoter region showed that the Hox-2.4 promoter contains a CCAAT box and a perfect octamer motif, which is capable of binding Oct-factors. Cotransfection of Oct expression vectors influences the transcriptional activity of the promoter, suggesting that the Oct-gene family may be involved in regulating HOX genes.

Entities: Gene Species

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Year: 1992 PMID： 1349742 PMCID： PMC312244 DOI： 10.1093/nar/20.7.1599

Source DB: PubMed Journal: Nucleic Acids Res ISSN： 0305-1048 Impact factor: 16.971

59 in total

The murine Hox-2.4 promoter contains a functional octamer motif.

1. The ubiquitous octamer-binding protein Oct-1 contains a POU domain with a homeo box subdomain.

2. Spatial regulation of homeobox gene fusions in the embryonic central nervous system of transgenic mice.

3. A human lymphoid-specific transcription factor that activates immunoglobulin genes is a homoeobox protein.

4. A cloned octamer transcription factor stimulates transcription from lymphoid-specific promoters in non-B cells.

Review 5. Expression of homeo box genes during mouse development: a review.

6. Homoeobox gene expression in mouse embryos varies with position by the primitive streak stage.

7. A ubiquitous mammalian expression vector, pHMG, based on a housekeeping gene promoter.

8. The murine and Drosophila homeobox gene complexes have common features of organization and expression.

9. A mouse homeobox containing gene on chromosome 11: sequence and tissue-specific expression.

10. Octamer binding proteins confer transcriptional activity in early mouse embryogenesis.

1. Regulation of Oct-4 gene expression during differentiation of EC cells.

2. Characterization of a negative retinoic acid response element in the murine Oct4 promoter.