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Literature DB >> 1349613

TNF-alpha suppresses CR3-mediated myelin removal by macrophages.

Abstract

Mononuclear cells of the monocyte/macrophage system play an important role in myelin ingestion during Wallerian degeneration. The present in vitro study clarifies the role in this process of two macrophage-secreted cytokines, TNF-alpha and interleukin-1. Treatment with TNF-alpha massively reduced the amount of myelin ingested by macrophages via their complement receptor type 3 (CR3). Anti-TNF-alpha antibodies reversed the effect. Immunofluorescence of macrophages indicated that TNF-alpha caused a reduced expression of the CR3 by phagocytic cells. Further experiments revealed an interaction of TNF-alpha with its receptor on the macrophage cell membrane. Interleukin-1 had no effect on myelin ingestion in the in vitro system used in these experiments.

Entities: Disease Gene

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Year: 1992 PMID： 1349613 DOI： 10.1016/0165-5728(92)90085-y

Source DB: PubMed Journal: J Neuroimmunol ISSN： 0165-5728 Impact factor: 3.478

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Cited

15 in total

1. Overcoming endogenous constraints on neuronal regeneration.

Authors: Nassir Mokarram; Ravi V Bellamkonda
Journal: IEEE Trans Biomed Eng Date: 2010-12-30 Impact factor: 4.538

2. Stimulation of adult oligodendrogenesis by myelin-specific T cells.

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Journal: Am J Pathol Date: 2011-08-26 Impact factor: 4.307

3. A role for complement in phagocytosis of myelin.

Authors: B A DeJong; M E Smith
Journal: Neurochem Res Date: 1997-04 Impact factor: 3.996

Review 4. The neuroimmunology of degeneration and regeneration in the peripheral nervous system.

Authors: A DeFrancesco-Lisowitz; J A Lindborg; J P Niemi; R E Zigmond
Journal: Neuroscience Date: 2014-09-19 Impact factor: 3.590

5. Biomaterial-mediated reprogramming of monocytes via microparticle phagocytosis for sustained modulation of macrophage phenotype.

Authors: Kathryn L Wofford; Bhavani S Singh; D Kacy Cullen; Kara L Spiller
Journal: Acta Biomater Date: 2019-11-13 Impact factor: 8.947

6. The cytokine network of Wallerian degeneration: tumor necrosis factor-alpha, interleukin-1alpha, and interleukin-1beta.

Authors: Shlomit Shamash; Fanny Reichert; Shlomo Rotshenker
Journal: J Neurosci Date: 2002-04-15 Impact factor: 6.167

TNF-alpha suppresses CR3-mediated myelin removal by macrophages.

1. Overcoming endogenous constraints on neuronal regeneration.

2. Stimulation of adult oligodendrogenesis by myelin-specific T cells.

3. A role for complement in phagocytosis of myelin.

Review 4. The neuroimmunology of degeneration and regeneration in the peripheral nervous system.

5. Biomaterial-mediated reprogramming of monocytes via microparticle phagocytosis for sustained modulation of macrophage phenotype.

6. The cytokine network of Wallerian degeneration: tumor necrosis factor-alpha, interleukin-1alpha, and interleukin-1beta.

7. Microglia activation and phagocytosis: relationship with aging and cognitive impairment in the rhesus monkey.

8. Mechanisms of macrophage recruitment in Wallerian degeneration.

9. Tumor necrosis factor expression during mouse hepatitis virus-induced demyelinating encephalomyelitis.

Review 10. Debris clearance by microglia: an essential link between degeneration and regeneration.