| Literature DB >> 7637037 |
S A Stohlman1, D R Hinton, D Cua, E Dimacali, J Sensintaffar, F M Hofman, S M Tahara, Q Yao.
Abstract
Neutralizing anti-tumor necrosis factor alpha (TNF-alpha) antibody treatment of mice infected with the neurotropic JHMV strain of mouse hepatitis virus showed no reduction of either virus-induced encephalomyelitis or central nervous system demyelination. TNF-alpha-positive cells were present in the central nervous system during infection; however, TNF-alpha could not be colocalized with JHMV-infected cells. In vitro, TNF-alpha mRNA rapidly accumulated following JHMV infection; however, no TNF-alpha was secreted because of inhibition of translation. Both live and UV-inactivated virus inhibited TNF-alpha secretion induced by lipopolysaccharide. These data show that TNF-alpha is not secreted from infected cells and indicate that if contributes to either JHMV-induced acute encephalomyelitis nor primary demyelination.Entities:
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Year: 1995 PMID： 7637037 PMCID： PMC189470
Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103