Literature DB >> 2234077

Requirement for hsp70 in the mitochondrial matrix for translocation and folding of precursor proteins.

P J Kang1, J Ostermann, J Shilling, W Neupert, E A Craig, N Pfanner.   

Abstract

By analysis of a temperature-sensitive yeast mutant, a heat-shock protein in the matrix of mitochondria, mitochondrial hsp70 (Ssc1p), is found to be involved both in translocation of nuclear-encoded precursor proteins across the mitochondrial membranes and in (re)folding of imported proteins in the matrix.

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Year:  1990        PMID： 2234077     DOI： 10.1038/348137a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  229 in total

Review 1.  Protein unfolding by mitochondria. The Hsp70 import motor.

Authors:  A Matouschek; N Pfanner; W Voos
Journal:  EMBO Rep       Date:  2000-11       Impact factor: 8.807

2.  Protein import channel of the outer mitochondrial membrane: a highly stable Tom40-Tom22 core structure differentially interacts with preproteins, small tom proteins, and import receptors.

Authors:  C Meisinger; M T Ryan; K Hill; K Model; J H Lim; A Sickmann; H Müller; H E Meyer; R Wagner; N Pfanner
Journal:  Mol Cell Biol       Date:  2001-04       Impact factor: 4.272

3.  Intragenic suppressors of Hsp70 mutants: interplay between the ATPase- and peptide-binding domains.

Authors:  J E Davis; C Voisine; E A Craig
Journal:  Proc Natl Acad Sci U S A       Date:  1999-08-03       Impact factor: 11.205

4.  The mitochondrial Hsp70-dependent import system actively unfolds preproteins and shortens the lag phase of translocation.

Authors:  J H Lim; F Martin; B Guiard; N Pfanner; W Voos
Journal:  EMBO J       Date:  2001-03-01       Impact factor: 11.598

5.  Coordinate and non-coordinate expression of the stress 70 family and other molecular chaperones at high and low temperature in spinach and tomato.

Authors:  Q B Li; D W Haskell; C L Guy
Journal:  Plant Mol Biol       Date:  1999-01       Impact factor: 4.076

6.  Membrane potential-driven protein import into mitochondria. The sorting sequence of cytochrome b(2) modulates the deltapsi-dependence of translocation of the matrix-targeting sequence.

Authors:  A Geissler; T Krimmer; U Bömer; B Guiard; J Rassow; N Pfanner
Journal:  Mol Biol Cell       Date:  2000-11       Impact factor: 4.138

7.  Mitochondrial protein import motor: the ATPase domain of matrix Hsp70 is crucial for binding to Tim44, while the peptide binding domain and the carboxy-terminal segment play a stimulatory role.

Authors:  T Krimmer; J Rassow; W H Kunau; W Voos; N Pfanner
Journal:  Mol Cell Biol       Date:  2000-08       Impact factor: 4.272

Review 8.  MCC and PSC, the putative protein import channels of mitochondria.

Authors:  K W Kinnally; C Muro; M L Campo
Journal:  J Bioenerg Biomembr       Date:  2000-02       Impact factor: 2.945

9.  Involvement of a chloroplast HSP70 heat shock protein in the integration of a protein (light-harvesting complex protein precursor) into the thylakoid membrane.

Authors:  S Yalovsky; H Paulsen; D Michaeli; P R Chitnis; R Nechushtai
Journal:  Proc Natl Acad Sci U S A       Date:  1992-06-15       Impact factor: 11.205

10.  The DNLZ/HEP zinc-binding subdomain is critical for regulation of the mitochondrial chaperone HSPA9.

Authors:  Michael T Vu; Peng Zhai; Juhye Lee; Cecilia Guerra; Shirley Liu; Michael C Gustin; Jonathan J Silberg
Journal:  Protein Sci       Date:  2012-01-04       Impact factor: 6.725
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