| Literature DB >> 1348246 |
H Jin1, D Oksenberg, A Ashkenazi, S J Peroutka, A M Duncan, R Rozmahel, Y Yang, G Mengod, J M Palacios, B F O'Dowd.
Abstract
We report the cloning of a human gene encoding the 5-hydroxytryptamine1B receptor. The receptor has the characteristics of a G-protein-linked receptor and is most homologous to the human 5-HT1D receptor. This human 5-HT receptor gene, most abundantly expressed in striatum, is localized on chromosome 6, at 6q13, and the gene encoding the 5-HT1D receptor is localized on chromosome 1. Radioligand studies indicate that the affinity of [3H]5-HT is 16 +/- 2 nM. Drug competition studies indicate that the receptor displays high affinity (i.e. less than 40 nM) for 5-HT, 5-carboxyamidotryptamine, methiothepin, and metergoline.Entities:
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Year: 1992 PMID： 1348246
Source DB: PubMed Journal: J Biol Chem ISSN： 0021-9258 Impact factor: 5.157