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Literature DB >> 1339292

Mouse liver cytochrome P-450 (P-450IIIAM1): its cDNA cloning and inducibility by dexamethasone.

T Yanagimoto¹, S Itoh, D Muller-Enoch, T Kamataki.

Abstract

A full-length cDNA complementary to mouse liver mRNA coding for one of the cytochromes P-450 (P-450) in the P-450IIIA family, namely P-450IIIM1, was isolated and completely sequenced. The sequence of this cDNA clone, pMDex13, revealed that it encoded a polypeptide of 504 deduced amino acid residues (Mr = 57,853). The deduced amino acid sequence showed 87.3 and 84.9% identity with rat P-450IIIA1 and P-450IIIA2, respectively. The NH2-terminal 24 amino acid sequences of P-450IIIAM1 were completely identical with purified mouse P-450UT protein. RNA blot analysis showed that mRNA content of hepatic P-450IIIAM1 was remarkably increased by treatment of mice with dexamethasone.

Entities: Chemical Gene Species

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Year: 1992 PMID： 1339292 DOI： 10.1016/0167-4781(92)90447-8

Source DB: PubMed Journal: Biochim Biophys Acta ISSN： 0006-3002

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Cited

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Mouse liver cytochrome P-450 (P-450IIIAM1): its cDNA cloning and inducibility by dexamethasone.

1. New nucleotide sequence data on the EMBL File Server.

2. Effects of ketoconazole on the biodistribution and metabolism of [11C]loperamide and [11C]N-desmethyl-loperamide in wild-type and P-gp knockout mice.

3. High-Fat Diets Alter the Modulatory Effects of Xenobiotics on Cytochrome P450 Activities.

4. The signal-anchor sequence of CYP2C1 inserts into the membrane as a hairpin structure.

5. Endocrine disruptors provoke differential modulatory responses on androgen receptor and pregnane and xenobiotic receptor: potential implications in metabolic disorders.

6. Chronopharmacokinetics of Erlotinib and Circadian Rhythms of Related Metabolic Enzymes in Lewis Tumor-Bearing Mice.

7. Effect of glucocorticoid-induced insulin resistance on follicle development and ovulation.

8. Role of CYP2A5 in the clearance of nicotine and cotinine: insights from studies on a Cyp2a5-null mouse model.

9. Induction of CYP3A and associated terfenadine N-dealkylation in rat hepatocytes cocultured with 3T3 cells.

10. Identification, induction and localization of cytochrome P450s of the 3A-subfamily in mouse brain.