Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Delayed hypersensitivity. II. Induction of hypersensitivity in guinea pigs by means of antigen-antibody complexes.

Literature DB >> 13385403

Delayed hypersensitivity. II. Induction of hypersensitivity in guinea pigs by means of antigen-antibody complexes.

Abstract

A general method for induction of the delayed hypersensitive state directed against single protein antigens is described. The method consists of intradermal injection of minute amounts of washed immune precipitates containing the antigen in question. Provided the specific precipitates are formed in the region of antibody excess, maximal sensitivity develops at least 2 to 3 weeks before detectable circulating antibody is formed in guinea pigs against the sensitizing antigen. Neither adjuvant nor killed acid-fast bacteria are required for induction of the delayed hypersensitive state although the degree of sensitization is considerably increased when the sensitizing material is incorporated in Freund's complete adjuvant. Characteristics of the "delayed" as opposed to the "immediate" hypersensitive states in the guinea pig are described and implications of the findings are discussed.

Entities: Disease Species

Keywords: IMMUNITY

Mesh：

Substances：

Year: 1957 PMID： 13385403 PMCID： PMC2136665 DOI： 10.1084/jem.105.1.11

Source DB: PubMed Journal: J Exp Med ISSN： 0022-1007 Impact factor: 14.307

12 in total

1. Passive cellular transfer of hypersensitivity to serum antigens in rabbits.

Authors: M M TREMAINE; W S JETER
Journal: J Immunol Date: 1955-02 Impact factor: 5.422

2. Antibody formation after injection of heterologous immune globulin.

Authors: F L ADLER
Journal: J Immunol Date: 1956-03 Impact factor: 5.422

3. In vitro production of diphtheria antitoxin by tissues of immunized animals. I. Procedure and evidence for general nature of phenomenon.

Authors: A B STAVITSKY
Journal: J Immunol Date: 1955-09 Impact factor: 5.422

4. Use of ultraviolet absorption spectroscopy in the quantitative precipitin reaction.

Authors: D GITLIN
Journal: J Immunol Date: 1949-08 Impact factor: 5.422

5. A quantitative study of the Arthus phenomenon induced passively in the guinea pig.

Authors: B BENACERRAF; E A KABAT
Journal: J Immunol Date: 1950-01 Impact factor: 5.422

6. Elicitation of delayed allergic skin reactions with haptens; the dependence of elicitation on hapten combination with protein.

Authors: H N EISEN; L ORRIS; S BELMAN
Journal: J Exp Med Date: 1952-05-01 Impact factor: 14.307

7. Immunochemical studies of antitoxin produced in normal and allergic individuals hyperimmunized with diphtheria toxoid. II. A comparison between the immunological properties of precipitating and non-precipitating (skin-sensitizing) antitoxins.

Authors: W J KUHNS; A M PAPPENHEIMER
Journal: J Exp Med Date: 1952-04 Impact factor: 14.307

8. STUDIES ON THE SENSITIZATION OF ANIMALS WITH SIMPLE CHEMICAL COMPOUNDS : VII. SKIN SENSITIZATION BY INTRAPERITONEAL INJECTIONS.

Authors: K Landsteiner; M W Chase
Journal: J Exp Med Date: 1940-01-31 Impact factor: 14.307

9. QUANTITATIVE EXPERIMENTS WITH ANTIBODIES TO A SPECIFIC PRECIPITATE. I.

Authors: H P Treffers; M Heidelberger
Journal: J Exp Med Date: 1941-01-01 Impact factor: 14.307

10. Transfer of delayed hypersensitivity to diphtheria toxin in man.

Authors: H S LAWRENCE; A M PAPPENHEIMER
Journal: J Exp Med Date: 1956-09-01 Impact factor: 14.307

45 in total

1. The control of the immune response: the significance of network theories.

Authors: P G Gell
Journal: J Clin Pathol Date: 1979-08 Impact factor: 3.411

2. STUDIES ON IMMUNITY AND PATHOGENESIS OF SALMONELLOSIS. II. ANTIBODY PRODUCTION AND ACCUMULATION OF BACTERIAL POLYSACCHARIDE IN THE TISSUES OF CHICKENS INFECTED WITH SALMONELLA GALLINARUM.

Authors: A BUXTON; J M DAVIES
Journal: Immunology Date: 1963-11 Impact factor: 7.397

10. Relationships among differentiated T-cell subpopulations. I. Dissociated development of tuberculin type hypersensitivity, Jones-Mote type hypersensitivity and activation of helper function.

Authors: Y Ohmichi; K Nomoto; H Yamada; K Takeya
Journal: Immunology Date: 1976-07 Impact factor: 7.397

Delayed hypersensitivity. II. Induction of hypersensitivity in guinea pigs by means of antigen-antibody complexes.

1. Passive cellular transfer of hypersensitivity to serum antigens in rabbits.

2. Antibody formation after injection of heterologous immune globulin.

3. In vitro production of diphtheria antitoxin by tissues of immunized animals. I. Procedure and evidence for general nature of phenomenon.

4. Use of ultraviolet absorption spectroscopy in the quantitative precipitin reaction.

5. A quantitative study of the Arthus phenomenon induced passively in the guinea pig.

6. Elicitation of delayed allergic skin reactions with haptens; the dependence of elicitation on hapten combination with protein.

7. Immunochemical studies of antitoxin produced in normal and allergic individuals hyperimmunized with diphtheria toxoid. II. A comparison between the immunological properties of precipitating and non-precipitating (skin-sensitizing) antitoxins.

8. STUDIES ON THE SENSITIZATION OF ANIMALS WITH SIMPLE CHEMICAL COMPOUNDS : VII. SKIN SENSITIZATION BY INTRAPERITONEAL INJECTIONS.

9. QUANTITATIVE EXPERIMENTS WITH ANTIBODIES TO A SPECIFIC PRECIPITATE. I.

10. Transfer of delayed hypersensitivity to diphtheria toxin in man.

1. The control of the immune response: the significance of network theories.

2. STUDIES ON IMMUNITY AND PATHOGENESIS OF SALMONELLOSIS. II. ANTIBODY PRODUCTION AND ACCUMULATION OF BACTERIAL POLYSACCHARIDE IN THE TISSUES OF CHICKENS INFECTED WITH SALMONELLA GALLINARUM.

3. [The antiglobulin consumption test. Its theoretical principles, technic and area of application].

4. Immunological aspects of rheumatoid disease: a review.

5. Immune and allergic reactions to diphtheria toxin and toxoid in guinea-pigs.

6. Auto-immune disease. I. Modern immunological concepts.

7. Production of pyrogenic substances in the reaction of cells of hypersensitive guinea pigs with antigen in vitro.

8. Induction of delayed-type hypersensitivity with BCG-associated proteins.

9. Inhibition by oxisuran of cell-mediated hypersensitivity by decrease in numbers of specifically sensitized cells.

10. Relationships among differentiated T-cell subpopulations. I. Dissociated development of tuberculin type hypersensitivity, Jones-Mote type hypersensitivity and activation of helper function.