Literature DB >> 133760

Androgen-dependent fibrinolytic activity in a murine mammary carcinoma (Shionogi SC-115 cells) in vitro.

T W Mak, G Rutledge, D J Sutherland.   

Abstract

Physiological concentrations of dihydrotestosterone (DHT) can specifically induce the release of fibrinolysin from androgen-dependent mammary carcinoma (Shionogi SC-115) cells in vitro. No fibrinolytic activity was observed in cells cultured either in the absence of DHT or presence of pharmacological concentrations of estrogen. Furthermore, an autonomous tumor derived from the Shionogi SC-115 cells produced fibrinolytic activity independent of added DHT or estrogen. These observations suggest a close correlation between fibrinolytic activity of a tumor and its ability to grow in vivo.

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Year:  1976        PMID： 133760     DOI： 10.1016/0092-8674(76)90021-0

Source DB:  PubMed          Journal:  Cell        ISSN： 0092-8674            Impact factor:   41.582


  18 in total

1.  Protease effects on specific growth properties of normal and transformed baby hamster kidney cells.

Authors:  M Brown; D Kiehn
Journal:  Proc Natl Acad Sci U S A       Date:  1977-07       Impact factor: 11.205

2.  cDNA and gene nucleotide sequence of porcine plasminogen activator.

Authors:  Y Nagamine; D Pearson; M S Altus; E Reich
Journal:  Nucleic Acids Res       Date:  1984-12-21       Impact factor: 16.971

3.  Growth promoting influences of estradiol, epidermal growth factor, and insulin on human breast cancer: evidence for differential mechanism of action on tumor cells in vitro.

Authors:  S Iacobelli; C Natoli
Journal:  Breast Cancer Res Treat       Date:  1985       Impact factor: 4.872

4.  Characterization of normal human embryo cells grown to over 100 population doublings.

Authors:  J A Poiley; R F Schuman; R J Pienta
Journal:  In Vitro       Date:  1978-05

Review 5.  The plasmin-antiplasmin system: structural and functional aspects.

Authors:  Johann Schaller; Simon S Gerber
Journal:  Cell Mol Life Sci       Date:  2010-12-07       Impact factor: 9.261

6.  The fibrinolytic system. A key to tumor metastasis?

Authors:  J M Malone; S L Wangensteen; W S Moore; K Keown
Journal:  Ann Surg       Date:  1979-09       Impact factor: 12.969

7.  Inhibition of protein synthesis in LLC-PK1 cells increases calcitonin-induced plasminogen-activator gene transcription and mRNA stability.

Authors:  M S Altus; D Pearson; A Horiuchi; Y Nagamine
Journal:  Biochem J       Date:  1987-03-01       Impact factor: 3.857

8.  Effect of dimethyl sulfoxide on human carcinoma cells, inhibition of plasminogen activator synthesis, change in cell morphology, and alteration of response to cholera toxin.

Authors:  L Ossowski; D Belin
Journal:  Mol Cell Biol       Date:  1985-12       Impact factor: 4.272

9.  Multiple nuclear factors interact with promoter sequences of the urokinase-type plasminogen activator gene.

Authors:  D von der Ahe; D Pearson; J Nakagawa; B Rajput; Y Nagamine
Journal:  Nucleic Acids Res       Date:  1988-08-11       Impact factor: 16.971

10.  Identification of a pituitary factor responsible for enhancement of plasminogen activator activity in breast tumor cells.

Authors:  R Mira-y-Lopez; J Joseph-Silverstein; D B Rifkin; L Ossowski
Journal:  Proc Natl Acad Sci U S A       Date:  1986-10       Impact factor: 11.205
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