Literature DB >> 1337432

Effects in vitro of two marine substances, chlorolissoclimide and dichlorolissoclimide, on a non-small-cell bronchopulmonary carcinoma line (NSCLC-N6).

C Malochet-Grivois1, C Roussakis, N Robillard, J F Biard, D Riou, C Débitus, J F Verbist.   

Abstract

The antiproliferative activity of two nitrogenous labdane cytotoxic substances from Lissoclinum voeltzkowi Michaelson (Urochordata), dichlorolissoclimide (P2) and chlorolissoclimide (P1), was studied in vitro on a continuous human non-small-cell bronchopulmonary carcinoma line (NSCLC-N6) at the cell cycle level. This antiproliferative effect resulted from a blockade of G1 phase cells. Mortality occurred, regardless of the degree of cell ploidy, with cell transition to an out-of-cycle situation characteristic of a G1D terminal maturation state.

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Year:  1992        PMID： 1337432

Source DB:  PubMed          Journal:  Anticancer Drug Des        ISSN： 0266-9536


  9 in total

Review 1.  Navigating the Chiral Pool in the Total Synthesis of Complex Terpene Natural Products.

Authors:  Zachary G Brill; Matthew L Condakes; Chi P Ting; Thomas J Maimone
Journal:  Chem Rev       Date:  2017-03-15       Impact factor: 60.622

Review 2.  Marine Mollusk-Derived Agents with Antiproliferative Activity as Promising Anticancer Agents to Overcome Chemotherapy Resistance.

Authors:  Maria Letizia Ciavatta; Florence Lefranc; Marianna Carbone; Ernesto Mollo; Margherita Gavagnin; Tania Betancourt; Ramesh Dasari; Alexander Kornienko; Robert Kiss
Journal:  Med Res Rev       Date:  2016-12-07       Impact factor: 12.944

Review 3.  Bioactive Compounds from Marine Heterobranchs.

Authors:  Conxita Avila; Carlos Angulo-Preckler
Journal:  Mar Drugs       Date:  2020-12-21       Impact factor: 5.118

4.  A Chlorine-Atom-Controlled Terminal-Epoxide-Initiated Bicyclization Cascade Enables a Synthesis of the Potent Cytotoxins Haterumaimides J and K.

Authors:  Sharon E Michalak; Sangkil Nam; David M Kwon; David A Horne; Christopher D Vanderwal
Journal:  J Am Chem Soc       Date:  2019-06-03       Impact factor: 15.419

5.  Site-Selective Aliphatic C-H Chlorination Using N-Chloroamides Enables a Synthesis of Chlorolissoclimide.

Authors:  Ryan K Quinn; Zef A Könst; Sharon E Michalak; Yvonne Schmidt; Anne R Szklarski; Alex R Flores; Sangkil Nam; David A Horne; Christopher D Vanderwal; Erik J Alexanian
Journal:  J Am Chem Soc       Date:  2016-01-06       Impact factor: 15.419

6.  Chlorolissoclimides: new inhibitors of eukaryotic protein synthesis.

Authors:  Francis Robert; Hong Qing Gao; Marwa Donia; William C Merrick; Mark T Hamann; Jerry Pelletier
Journal:  RNA       Date:  2006-03-15       Impact factor: 4.942

Review 7.  The Recurring Roles of Chlorine in Synthetic and Biological Studies of the Lissoclimides.

Authors:  Bonnie S Pak; Nantamon Supantanapong; Christopher D Vanderwal
Journal:  Acc Chem Res       Date:  2021-02-05       Impact factor: 22.384

Review 8.  Marine Natural Products from New Caledonia--A Review.

Authors:  Sofia-Eléna Motuhi; Mohamed Mehiri; Claude Elisabeth Payri; Stéphane La Barre; Stéphane Bach
Journal:  Mar Drugs       Date:  2016-03-16       Impact factor: 5.118

9.  Synthesis facilitates an understanding of the structural basis for translation inhibition by the lissoclimides.

Authors:  Zef A Könst; Anne R Szklarski; Simone Pellegrino; Sharon E Michalak; Mélanie Meyer; Camila Zanette; Regina Cencic; Sangkil Nam; Vamsee K Voora; David A Horne; Jerry Pelletier; David L Mobley; Gulnara Yusupova; Marat Yusupov; Christopher D Vanderwal
Journal:  Nat Chem       Date:  2017-07-03       Impact factor: 24.427
  9 in total

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