Literature DB >> 1336491

Phenotypic properties of liver tumors induced by dehydroepiandrosterone in F-344 rats.

M S Rao1, V Subbarao, S Kumar, A V Yeldandi, J K Reddy.   

Abstract

Dehydroepiandrosterone (DHEA), a C19 adrenal steroid hormone, induces peroxisome proliferation in liver cells and is hepatocarcinogenic in the rat. The present study deals with the phenotypic properties of DHEA-induced liver lesions. A majority of the altered areas (80-87%), neoplastic nodules (> 94%) and hepatocellular carcinomas (HCC, 80-100%) lacked the marker enzymes gamma-glutamyltranspeptidase and placental form of glutathione S-transferase (GSTP). Northern blot analysis of HCC from 4 rats revealed no detectable GSTP mRNA. These HCC, however, showed a marked decrease in the staining of glucose-6-phosphatase and adenosine triphosphatase. These results indicate that the phenotypic properties of liver tumors induced by DHEA and amphipathic carboxylate peroxisome proliferators are similar.

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Year:  1992        PMID： 1336491      PMCID： PMC5918701          DOI： 10.1111/j.1349-7006.1992.tb02742.x

Source DB:  PubMed          Journal:  Jpn J Cancer Res        ISSN： 0910-5050


altered areas a‐fetoprotein adenosinetriphosphatase dehydroepiandrosterone glucose‐6‐phosphatase γM‐glutamyltranspeptidase glutathione S‐transferase, placental form hepatocellular carcinoma neoplastic nodules peroxisome proliferators
  32 in total

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Authors:  I Issemann; S Green
Journal:  Nature       Date:  1990-10-18       Impact factor: 49.962

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Journal:  Adv Cancer Res       Date:  1989       Impact factor: 6.242

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Authors:  T Mitaka; H Tsukada
Journal:  Jpn J Cancer Res       Date:  1987-08

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Authors:  M H Hanigan; H C Pitot
Journal:  Carcinogenesis       Date:  1985-02       Impact factor: 4.944

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Journal:  Proc Natl Acad Sci U S A       Date:  1984-08       Impact factor: 11.205

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Journal:  Tumour Biol       Date:  1986

7.  Lack of expression of glutathione-S-transferase P, gamma-glutamyl transpeptidase, and alpha-fetoprotein messenger RNAs in liver tumors induced by peroxisome proliferators.

Authors:  M S Rao; M R Nemali; N Usuda; D G Scarpelli; T Makino; H C Pitot; J K Reddy
Journal:  Cancer Res       Date:  1988-09-01       Impact factor: 12.701

8.  Induction of microsomal NADPH-cytochrome P-450 reductase and cytochrome P-450IVA1 (P-450LA omega) by dehydroepiandrosterone in rats: a possible peroxisomal proliferator.

Authors:  H Q Wu; J Masset-Brown; D J Tweedie; L Milewich; R A Frenkel; C Martin-Wixtrom; R W Estabrook; R A Prough
Journal:  Cancer Res       Date:  1989-05-01       Impact factor: 12.701

9.  Peroxisome proliferator-induced hepatocarcinogenesis: histochemical analysis of ciprofibrate-induced preneoplastic and neoplastic lesions for gamma-glutamyl transpeptidase activity.

Authors:  M S Rao; V Subbarao; J K Reddy
Journal:  J Natl Cancer Inst       Date:  1986-10       Impact factor: 13.506

10.  Loss of peroxisomal enzyme expression in preneoplastic and neoplastic lesions induced by peroxisome proliferators in rat livers.

Authors:  Y Yokoyama; S Tsuchida; I Hatayama; K Satoh; T Narita; M S Rao; J K Reddy; J Yamada; T Suga; K Sato
Journal:  Carcinogenesis       Date:  1992-02       Impact factor: 4.944
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Review 1.  Fish models for environmental carcinogenesis: the rainbow trout.

Authors:  G S Bailey; D E Williams; J D Hendricks
Journal:  Environ Health Perspect       Date:  1996-03       Impact factor: 9.031

Review 2.  Animal Models: A Useful Tool to Unveil Metabolic Changes in Hepatocellular Carcinoma.

Authors:  Marina Serra; Amedeo Columbano; Andrea Perra; Marta Anna Kowalik
Journal:  Cancers (Basel)       Date:  2020-11-10       Impact factor: 6.639

3.  Modulation of dihydroxy-di-n-propylnitrosamine-induced liver lesion development in Opisthorchis-infected Syrian hamsters by praziquantel treatment in association with butylated hydroxyanisole or dehydroepiandrosterone administration.

Authors:  M A Moore; W Thamavit; D Tiwawech; N Ito; H Tsuda
Journal:  Jpn J Cancer Res       Date:  1998-11
  3 in total

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