Literature DB >> 1330591

PPADS, a novel functionally selective antagonist of P2 purinoceptor-mediated responses.

G Lambrecht1, T Friebe, U Grimm, U Windscheif, E Bungardt, C Hildebrandt, H G Bäumert, G Spatz-Kümbel, E Mutschler.   

Abstract

We have characterized PPADS (pyridoxalphosphate-6-azophenyl-2',4'-disulfonic acid) as a novel antagonist which selectively blocks P2 purinoceptor-mediated responses in rabbit vas deferens at pre- and postjunctional sites. PPADS did not interact with alpha 1-adrenoceptors, muscarinic M2 and M3 receptors, histamine H1 and adenosine A1 receptors. Thus, PPADS is a novel and useful pharmacological tool to study co-transmission in tissues where ATP and co-existing neurotransmitters act in concert.

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Year:  1992        PMID： 1330591     DOI： 10.1016/0014-2999(92)90877-7

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  90 in total

1.  ATP-Induced Ca(2+) release in cochlear outer hair cells: localization of an inositol triphosphate-gated Ca(2+) store to the base of the sensory hair bundle.

Authors:  F Mammano; G I Frolenkov; L Lagostena; I A Belyantseva; M Kurc; V Dodane; A Colavita; B Kachar
Journal:  J Neurosci       Date:  1999-08-15       Impact factor: 6.167

2.  Distinct mechanisms underlying alpha1-adrenoceptor and P2x purinoceptor operated ATP release and contraction in the guinea-pig vas deferens.

Authors:  B Sperlágh; P Illes; Z Gerevich; A Köfalvi
Journal:  Neurochem Res       Date:  2001-09       Impact factor: 3.996

3.  Potentiation of capsaicin receptor activity by metabotropic ATP receptors as a possible mechanism for ATP-evoked pain and hyperalgesia.

Authors:  M Tominaga; M Wada; M Masu
Journal:  Proc Natl Acad Sci U S A       Date:  2001-05-22       Impact factor: 11.205

Review 4.  Molecular recognition in P2 receptors: ligand development aided by molecular modeling and mutagenesis.

Authors:  K A Jacobson; C Hoffmann; Y C Kim; E Camaioni; E Nandanan; S Y Jang; D P Guo; X D Ji; I von Kügelgen; S Moro; A U Ziganshin; A Rychkov; B F King; S G Brown; S S Wildman; G Burnstock; J L Boyer; A Mohanram; T K Harden
Journal:  Prog Brain Res       Date:  1999       Impact factor: 2.453

5.  Development of a comprehensive set of P2 receptor pharmacological research compounds.

Authors:  R A Felix; S Martin; S Pinion; D J Crawford
Journal:  Purinergic Signal       Date:  2011-11-04       Impact factor: 3.765

6.  Potentiation of sympathetic neuromuscular transmission mediated by muscarinic receptors in guinea pig isolated vas deferens.

Authors:  Samera Iram; Charles H V Hoyle
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2005-04-05       Impact factor: 3.000

Review 7.  Pharmacology of P2X channels.

Authors:  Joel R Gever; Debra A Cockayne; Michael P Dillon; Geoffrey Burnstock; Anthony P D W Ford
Journal:  Pflugers Arch       Date:  2006-04-29       Impact factor: 3.657

8.  Ionotropic P2X purinoreceptors mediate synaptic transmission in rat pyramidal neurones of layer II/III of somato-sensory cortex.

Authors:  Y Pankratov; U Lalo; O Krishtal; A Verkhratsky
Journal:  J Physiol       Date:  2002-07-15       Impact factor: 5.182

9.  The use of antagonists to characterize the receptors mediating depolarization of the rat isolated vagus nerve by alpha, beta-methylene adenosine 5'-triphosphate.

Authors:  D J Trezise; I Kennedy; P P Humphrey
Journal:  Br J Pharmacol       Date:  1994-05       Impact factor: 8.739

10.  P2X purinoceptors in cultured myenteric neurons of guinea-pig small intestine.

Authors:  X Zhou; J J Galligan
Journal:  J Physiol       Date:  1996-11-01       Impact factor: 5.182
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