Literature DB >> 10550992

Molecular recognition in P2 receptors: ligand development aided by molecular modeling and mutagenesis.

K A Jacobson1, C Hoffmann, Y C Kim, E Camaioni, E Nandanan, S Y Jang, D P Guo, X D Ji, I von Kügelgen, S Moro, A U Ziganshin, A Rychkov, B F King, S G Brown, S S Wildman, G Burnstock, J L Boyer, A Mohanram, T K Harden.   

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Year:  1999        PMID： 10550992      PMCID： PMC4321826          DOI： 10.1016/s0079-6123(08)63550-5

Source DB:  PubMed          Journal:  Prog Brain Res        ISSN： 0079-6123            Impact factor:   2.453


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  23 in total

1.  Slow desensitization of the human P2Y6 receptor.

Authors:  B Robaye; J M Boeynaems; D Communi
Journal:  Eur J Pharmacol       Date:  1997-06-25       Impact factor: 4.432

2.  Structure-activity relationships of bisphosphate nucleotide derivatives as P2Y1 receptor antagonists and partial agonists.

Authors:  E Nandanan; E Camaioni; S Y Jang; Y C Kim; G Cristalli; P Herdewijn; J A Secrist; K N Tiwari; A Mohanram; T K Harden; J L Boyer; K A Jacobson
Journal:  J Med Chem       Date:  1999-05-06       Impact factor: 7.446

3.  Cloning of a human purinergic P2Y receptor coupled to phospholipase C and adenylyl cyclase.

Authors:  D Communi; C Govaerts; M Parmentier; J M Boeynaems
Journal:  J Biol Chem       Date:  1997-12-19       Impact factor: 5.157

4.  PPADS and suramin as antagonists at cloned P2Y- and P2U-purinoceptors.

Authors:  S J Charlton; C A Brown; G A Weisman; J T Turner; L Erb; M R Boarder
Journal:  Br J Pharmacol       Date:  1996-06       Impact factor: 8.739

5.  Deoxyadenosine bisphosphate derivatives as potent antagonists at P2Y1 receptors.

Authors:  E Camaioni; J L Boyer; A Mohanram; T K Harden; K A Jacobson
Journal:  J Med Chem       Date:  1998-01-15       Impact factor: 7.446

6.  A mutational analysis of residues essential for ligand recognition at the human P2Y1 receptor.

Authors:  Q Jiang; D Guo; B X Lee; A M Van Rhee; Y C Kim; R A Nicholas; J B Schachter; T K Harden; K A Jacobson
Journal:  Mol Pharmacol       Date:  1997-09       Impact factor: 4.436

7.  Phosphoinositide hydrolysis by guanosine 5'-[gamma-thio]triphosphate-activated phospholipase C of turkey erythrocyte membranes.

Authors:  T K Harden; P T Hawkins; L Stephens; J L Boyer; C P Downes
Journal:  Biochem J       Date:  1988-06-01       Impact factor: 3.857

8.  Site-directed mutagenesis of P2U purinoceptors. Positively charged amino acids in transmembrane helices 6 and 7 affect agonist potency and specificity.

Authors:  L Erb; R Garrad; Y Wang; T Quinn; J T Turner; G A Weisman
Journal:  J Biol Chem       Date:  1995-03-03       Impact factor: 5.157

9.  Synthesis and Structure-Activity Relationships of Pyridoxal-6-arylazo-5'-phosphate and Phosphonate Derivatives as P2 Receptor Antagonists.

Authors:  Yong-Chul Kim; Emidio Camaioni; Airat U Ziganshin; Xiao-Duo Ji; Brian F King; Scott S Wildman; Alexei Rychkov; Joshua Yoburn; Heaok Kim; Arvind Mohanram; T Kendall Harden; José L Boyer; Geoffrey Burnstock; Kenneth A Jacobson
Journal:  Drug Dev Res       Date:  1998-10-01       Impact factor: 4.360

10.  Second messenger cascade specificity and pharmacological selectivity of the human P2Y1-purinoceptor.

Authors:  J B Schachter; Q Li; J L Boyer; R A Nicholas; T K Harden
Journal:  Br J Pharmacol       Date:  1996-05       Impact factor: 8.739
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  8 in total

1.  Structure-activity relationships of bisphosphate nucleotide derivatives as P2Y1 receptor antagonists and partial agonists.

Authors:  E Nandanan; E Camaioni; S Y Jang; Y C Kim; G Cristalli; P Herdewijn; J A Secrist; K N Tiwari; A Mohanram; T K Harden; J L Boyer; K A Jacobson
Journal:  J Med Chem       Date:  1999-05-06       Impact factor: 7.446

Review 2.  P2Y receptors in the mammalian nervous system: pharmacology, ligands and therapeutic potential.

Authors:  Gary A Weisman; Lucas T Woods; Laurie Erb; Cheikh I Seye
Journal:  CNS Neurol Disord Drug Targets       Date:  2012-09       Impact factor: 4.388

3.  Purine- and pyrimidine-induced responses and P2Y receptor characterization in the hamster proximal urethra.

Authors:  Christian Pinna; Rainer Glass; Gillian E Knight; Chiara Bolego; Lina Puglisi; Geoffrey Burnstock
Journal:  Br J Pharmacol       Date:  2005-02       Impact factor: 8.739

Review 4.  P2 receptors for extracellular nucleotides in the central nervous system: role of P2X7 and P2Y₂ receptor interactions in neuroinflammation.

Authors:  Gary A Weisman; Jean M Camden; Troy S Peterson; Deepa Ajit; Lucas T Woods; Laurie Erb
Journal:  Mol Neurobiol       Date:  2012-04-01       Impact factor: 5.590

5.  Actions of a Series of PPADS Analogs at P2X1 and P2X3 Receptors.

Authors:  Sean G Brown; Yong-Chul Kim; Soon-Ai Kim; Kenneth A Jacobson; Geoffrey Burnstock; Brian F King
Journal:  Drug Dev Res       Date:  2001-10-18       Impact factor: 4.360

6.  Evidence for the Recognition of Non-Nucleotide Antagonists Within the Transmembrane Domains of the Human P2Y(1) Receptor.

Authors:  Danping Guo; Ivar von Kügelgen; Stefano Moro; Yong-Chul Kim; Kenneth A Jacobson
Journal:  Drug Dev Res       Date:  2003-01-22       Impact factor: 4.360

7.  ATP analogues with modified phosphate chains and their selectivity for rat P2X2 and P2X2/3 receptors.

Authors:  Valeria Spelta; Abdelaziz Mekhalfia; Dominik Rejman; Mark Thompson; G Michael Blackburn; R Alan North
Journal:  Br J Pharmacol       Date:  2003-10-27       Impact factor: 8.739

Review 8.  Burnstock and the legacy of the inhibitory junction potential and P2Y1 receptors.

Authors:  Brian F King
Journal:  Purinergic Signal       Date:  2020-10-30       Impact factor: 3.765
  8 in total

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