Literature DB >> 1330028

Conditional probability analysis for a domain model of Ca(2+)-inactivation of Ca2+ channels.

J Keizer1, L W Maki.   

Abstract

The domain model of Ca2+ inactivation of Ca2+ channels, which has been used to explain rapid inactivation of whole cell Ca2+ currents in pancreatic beta cells, is applied to single-time and conditional open probability measurements on guinea pig ventricular myocyte Ca2+ channels. These two measurements greatly constrain the choice of kinetic constants in the model. Calculations with the model provide a simple quantitative explanation of recent experimental results, including a slow increase in the inactivation rate.

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Year:  1992        PMID： 1330028      PMCID： PMC1262146          DOI： 10.1016/S0006-3495(92)81576-X

Source DB:  PubMed          Journal:  Biophys J        ISSN： 0006-3495            Impact factor:   4.033


  9 in total

1.  Inactivation kinetics and pharmacology distinguish two calcium currents in mouse pancreatic B-cells.

Authors:  W F Hopkins; L S Satin; D L Cook
Journal:  J Membr Biol       Date:  1991-02       Impact factor: 1.843

2.  Diffusion-controlled binding of a peptide neurotoxin to its K+ channel receptor.

Authors:  C Miller
Journal:  Biochemistry       Date:  1990-06-05       Impact factor: 3.162

3.  Compartmentalization of the submembrane calcium activity during calcium influx and its significance in transmitter release.

Authors:  S M Simon; R R Llinás
Journal:  Biophys J       Date:  1985-09       Impact factor: 4.033

4.  Domain model for Ca2(+)-inactivation of Ca2+ channels at low channel density.

Authors:  A Sherman; J Keizer; J Rinzel
Journal:  Biophys J       Date:  1990-10       Impact factor: 4.033

Review 5.  Inactivation of Ca channels.

Authors:  R Eckert; J E Chad
Journal:  Prog Biophys Mol Biol       Date:  1984       Impact factor: 3.667

6.  Single channel studies on inactivation of calcium currents.

Authors:  H D Lux; A M Brown
Journal:  Science       Date:  1984-07-27       Impact factor: 47.728

7.  Calcium domains associated with individual channels can account for anomalous voltage relations of CA-dependent responses.

Authors:  J E Chad; R Eckert
Journal:  Biophys J       Date:  1984-05       Impact factor: 4.033

8.  Calcium-sensitive inactivation in the gating of single calcium channels.

Authors:  D T Yue; P H Backx; J P Imredy
Journal:  Science       Date:  1990-12-21       Impact factor: 47.728

9.  Cardiac calcium channels in planar lipid bilayers. L-type channels and calcium-permeable channels open at negative membrane potentials.

Authors:  R L Rosenberg; P Hess; R W Tsien
Journal:  J Gen Physiol       Date:  1988-07       Impact factor: 4.086
  9 in total
  1 in total

1.  Ca(2+)-dependent inactivation of a cloned cardiac Ca2+ channel alpha 1 subunit (alpha 1C) expressed in Xenopus oocytes.

Authors:  A Neely; R Olcese; X Wei; L Birnbaumer; E Stefani
Journal:  Biophys J       Date:  1994-06       Impact factor: 4.033
  1 in total

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