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Literature DB >> 13284565

Synthetic substances with morphine-like effect; relationship between chemical structure and analgesic action.

Abstract

For morphine-, morphinan-, pethidine-, methadone-, and dithienyl-butenylamine groups of analgesic compounds a systematic survey is given of how analgesic activity is quantitatively affected by alteration of the chemical constitution. Features common to the structural formulae of substances with morphine-like analgesic effect are pointed out.

Entities: Chemical

Keywords: ANALGESICS/effects

Mesh：

Substances：

Year: 1955 PMID： 13284565 PMCID： PMC2538094

Source DB: PubMed Journal: Bull World Health Organ ISSN： 0042-9686 Impact factor: 9.408

34 in total

1. N-Allylnormorphine: effects of single doses and precipitation of acute abstinence syndromes during addiction to morphine; methadone or heroin in man (post addicts).

Authors: A WIKLER; H F FRASER; H ISBELL
Journal: J Pharmacol Exp Ther Date: 1953-09 Impact factor: 4.030

2. N-Allylnormorphine as an antagonist to the intestinal spasm produced by the addicting analgesics.

Authors: C M GRUBER; C M GRUBER
Journal: J Pharmacol Exp Ther Date: 1953-10 Impact factor: 4.030

3. [New analgesic promedol].

Authors: I N NAZAROV; M D MASHKOVSKII; V A RUDENKO; N S PROSTAKOV; V I ISHCHENKO
Journal: Klin Med (Mosk) Date: 1952-08

4. N-allylnormorphine in treatment of dihydromorphinone and methorphinan overdosage; report of a case.

Authors: H F CHASE; R S BOYD; P M ANDREWS
Journal: J Am Med Assoc Date: 1952-11-15

5. Some morphine-like properties of (+/-)-cyclohexyloxy-alpha-phenylethylamines.

Authors: A MCCOUBREY
Journal: Br J Pharmacol Chemother Date: 1953-03

6. Synthetic analgesics. II. Dithienylbutenyl- and dithienylbutylamines.

Authors: N B EDDY; D LEIMBACH
Journal: J Pharmacol Exp Ther Date: 1953-03 Impact factor: 4.030

7. [Morphine antagonists].

Authors: K FROMHERZ; B PELLMONT
Journal: Experientia Date: 1952-10-15

8. An evaluation of the analgetic activity of the dromoran isomers.

Authors: M B SLOMKA; E G GROSS
Journal: Proc Soc Exp Biol Med Date: 1952-11

9. Combating narcotic-induced respiratory depression in surgery.

Authors: J ADRIANI
Journal: Merck Rep Date: 1953-04

10. Nalorphine (Nalline) antagonism to race-morphan (Dromoran) intoxication.

Authors: E F DOMINO; E W PELIKAN; E F TRAUT
Journal: J Am Med Assoc Date: 1953-09-05

15 in total

1. Similarly between receptors responsible for the production of analgesia and lenticular opacity.

Authors: M WEINSTOCK
Journal: Br J Pharmacol Chemother Date: 1961-12

2. The biological disposition of morphine and its surrogates. I.

Authors: E L WAY; T K ADLER
Journal: Bull World Health Organ Date: 1961 Impact factor: 9.408

3. The biological disposition of morphine and its surrogates.

Authors: E L WAY; T K ADLER
Journal: Bull World Health Organ Date: 1962 Impact factor: 9.408

4. Addiction liability and narcotics control.

Authors: N B EDDY; H ISBELL
Journal: Public Health Rep Date: 1959-09 Impact factor: 2.792

5. Analgesic action of ethyl 4-phenylpiperidine-4-carboxylates with oxygenated 1-substituents.

Authors: A M BLAIR; R P STEPHENSON
Journal: Br J Pharmacol Chemother Date: 1960-06

6. Synthetic substances with morphine-like effect; relationship between analgesic action and addiction liability, with a discussion of the chemical structure of addiction-producing substances.

Authors: N B EDDY; H HALBACH; O J BRAENDEN
Journal: Bull World Health Organ Date: 1956 Impact factor: 9.408