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Literature DB >> 14005775

Similarly between receptors responsible for the production of analgesia and lenticular opacity.

Abstract

Evidence is presented that the receptors responsible for the mediation of analgesia by morphine-like drugs are similar to those which are involved in the production of a reversible lenticular opacity. The activity of a number of compounds in mice on the lens was closely correlated with analgesic potency in this species. Stereospecificity for isomers with D configuration was demonstrated for both effects. Nalorphine only antagonized the lenticular opacity activity of those drugs the analgesic action of which it abolished.

Entities: Chemical Disease Species

Keywords: ANALGESICS AND ANTIPYRETICS/pharmacology; LENS, CRYSTALLINE/pharmacology

Mesh：

Substances：

Year: 1961 PMID： 14005775 PMCID： PMC1482082 DOI： 10.1111/j.1476-5381.1961.tb01130.x

Source DB: PubMed Journal: Br J Pharmacol Chemother ISSN： 0366-0826

11 in total

1. Lenticular effect in mice of some morphine-like drugs.

Authors: M WEINSTOCK; H C STEWART; K R BUTTERWORTH
Journal: Nature Date: 1958-11-29 Impact factor: 49.962

2. Analgesics and their antagonists: some steric and chemical considerations. III. The influence of the basic group on the biological response.

Authors: A H BECKETT; A F CASY; N J HARPER
Journal: J Pharm Pharmacol Date: 1956-11 Impact factor: 3.765

3. Synthetic analgesics: stereochemical considerations.

Authors: A H BECKETT; A F CASY
Journal: J Pharm Pharmacol Date: 1954-12 Impact factor: 3.765

4. Pharmacological studies of mixtures of narcotics and N-allylnormorphine.

Authors: P D ORAHOVATS; C A WINTER; E G LEHMAN
Journal: J Pharmacol Exp Ther Date: 1954-10 Impact factor: 4.030

5. Effects of N-allylnormorphine upon the respiratory depression due to morphine in anesthetized man with studies on the respiratory response to carbon dioxide.

Authors: C M LANDMESSER; S COBB; J G CONVERSE
Journal: Anesthesiology Date: 1953-11 Impact factor: 7.892

10. A new series of potent analgesics: dextro 2:2-diphenyl-3-methyl-4-morpholino-butyrylpyrrolidine and related amides. I. Chemical structure and pharmacological activity.

Authors: P A JANSSEN; A H JAGENEAU
Journal: J Pharm Pharmacol Date: 1957-06 Impact factor: 3.765

3 in total

Similarly between receptors responsible for the production of analgesia and lenticular opacity.

1. Lenticular effect in mice of some morphine-like drugs.

2. Analgesics and their antagonists: some steric and chemical considerations. III. The influence of the basic group on the biological response.

3. Synthetic analgesics: stereochemical considerations.

4. Pharmacological studies of mixtures of narcotics and N-allylnormorphine.

5. Effects of N-allylnormorphine upon the respiratory depression due to morphine in anesthetized man with studies on the respiratory response to carbon dioxide.

6. Synthetic analgesics. II. Dithienylbutenyl- and dithienylbutylamines.

7. Conjugation of N-allylnormorphine by liver slices.

8. OCCURRENCE IN RODENTS OF REVERSIBLE DRUG-INDUCED OPACITIES OF THE LENS.

9. Nalorphine (n-allylnormorphine); practical and theoretical considerations.

10. A new series of potent analgesics: dextro 2:2-diphenyl-3-methyl-4-morpholino-butyrylpyrrolidine and related amides. I. Chemical structure and pharmacological activity.

1. The role of the sympathetic nervous system in mediating the action of analgesic drugs on the lens.

2. The effect of analgesic drugs on the release of acetylcholine from electrically stimulated guinea-pig ileum.

3. QUANTITATIVE STUDIES OF THE ANTAGONISM BY NALORPHINE OF SOME OF THE ACTIONS OF MORPHINE-LIKE ANALGESIC DRUGS.