Literature DB >> 1327192

Variation in serum levels of the soluble TNF receptors among healthy individuals.

D Aderka1, H Engelmann, Y Shemer-Avni, V Hornik, A Galil, B Sarov, D Wallach.   

Abstract

Soluble forms of the two receptors for tumor necrosis factor (TNF) are present in human sera at concentrations that increase greatly in various disease states as well as varying among healthy individuals. Measurements of the soluble TNF receptor (sTNF-R) concentrations in healthy individuals at time lapses of 3 months (17 individuals) or 1 year (51 individuals) showed a significant correlation between the first and the second measurements from each individual, implying that individual differences are stable. Since the sTNF-Rs are believed to function as physiological attenuators of TNF activity, these steady individual differences may contribute to differences in the severity of the harmful effects of TNF in disease states.

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Year:  1992        PMID： 1327192

Source DB:  PubMed          Journal:  Lymphokine Cytokine Res        ISSN： 1056-5477


  36 in total

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