BACKGROUND: There is growing evidence that higher levels of inflammatory markers are associated with physical decline in older persons, possibly through the catabolic effects of inflammatory markers on muscle. The aim of this study was to investigate the association between serum levels of inflammatory markers and loss of muscle mass and strength in older persons. METHODS: Using data on 2,177 men and women in the Health, Aging, and Body Composition Study, we examined 5-year change in thigh muscle area estimated by computed tomography and grip and knee extensor strength in relation to serum levels of interleukin-6 (IL-6), C-reactive protein, tumor necrosis factor-alpha (TNF-alpha), and soluble receptors (measured in a subsample) at baseline. RESULTS: Higher levels of inflammatory markers were generally associated with greater 5-year decline in thigh muscle area. Most associations, with the exception of soluble receptors, were attenuated by adjustment for 5-year change in weight. Higher TNF-alpha and interleukin-6 soluble receptor levels remained associated with greater decline in grip strength in men. Analyses in a subgroup of weight-stable persons showed that higher levels of TNF-alpha and its soluble receptors were associated with 5-year decline in thigh muscle area and that higher levels of TNF-alpha were associated with decline in grip strength. CONCLUSIONS: TNF-alpha and its soluble receptors showed the most consistent associations with decline in muscle mass and strength. The results suggest a weight-associated pathway for inflammation in sarcopenia.
BACKGROUND: There is growing evidence that higher levels of inflammatory markers are associated with physical decline in older persons, possibly through the catabolic effects of inflammatory markers on muscle. The aim of this study was to investigate the association between serum levels of inflammatory markers and loss of muscle mass and strength in older persons. METHODS: Using data on 2,177 men and women in the Health, Aging, and Body Composition Study, we examined 5-year change in thigh muscle area estimated by computed tomography and grip and knee extensor strength in relation to serum levels of interleukin-6 (IL-6), C-reactive protein, tumor necrosis factor-alpha (TNF-alpha), and soluble receptors (measured in a subsample) at baseline. RESULTS: Higher levels of inflammatory markers were generally associated with greater 5-year decline in thigh muscle area. Most associations, with the exception of soluble receptors, were attenuated by adjustment for 5-year change in weight. Higher TNF-alpha and interleukin-6 soluble receptor levels remained associated with greater decline in grip strength in men. Analyses in a subgroup of weight-stable persons showed that higher levels of TNF-alpha and its soluble receptors were associated with 5-year decline in thigh muscle area and that higher levels of TNF-alpha were associated with decline in grip strength. CONCLUSIONS:TNF-alpha and its soluble receptors showed the most consistent associations with decline in muscle mass and strength. The results suggest a weight-associated pathway for inflammation in sarcopenia.
Authors: B H Goodpaster; C L Carlson; M Visser; D E Kelley; A Scherzinger; T B Harris; E Stamm; A B Newman Journal: J Appl Physiol (1985) Date: 2001-06
Authors: Luigi Ferrucci; Brenda W J H Penninx; Stefano Volpato; Tamara B Harris; Karen Bandeen-Roche; Jennifer Balfour; Suzanne G Leveille; Linda P Fried; Jack M Guralnik Md Journal: J Am Geriatr Soc Date: 2002-12 Impact factor: 5.562
Authors: Marjolein Visser; Marco Pahor; Dennis R Taaffe; Bret H Goodpaster; Eleanor M Simonsick; Anne B Newman; Michael Nevitt; Tamara B Harris Journal: J Gerontol A Biol Sci Med Sci Date: 2002-05 Impact factor: 6.053
Authors: Hélène Payette; Ronenn Roubenoff; Paul F Jacques; Charles A Dinarello; Peter W F Wilson; Leslie W Abad; Tamara Harris Journal: J Am Geriatr Soc Date: 2003-09 Impact factor: 5.562
Authors: Daniel R Cottam; Samer G Mattar; Emma Barinas-Mitchell; George Eid; Lewis Kuller; David E Kelley; Philip R Schauer Journal: Obes Surg Date: 2004-05 Impact factor: 4.129
Authors: Ramachandran S Vasan; Lisa M Sullivan; Ronenn Roubenoff; Charles A Dinarello; Tamara Harris; Emelia J Benjamin; Douglas B Sawyer; Daniel Levy; Peter W F Wilson; Ralph B D'Agostino Journal: Circulation Date: 2003-03-25 Impact factor: 29.690
Authors: Matteo Cesari; Brenda W J H Penninx; Marco Pahor; Fulvio Lauretani; Anna Maria Corsi; G Rhys Williams; Jack M Guralnik; Luigi Ferrucci Journal: J Gerontol A Biol Sci Med Sci Date: 2004-03 Impact factor: 6.053
Authors: Stephen D Anton; Adam J Woods; Tetso Ashizawa; Diana Barb; Thomas W Buford; Christy S Carter; David J Clark; Ronald A Cohen; Duane B Corbett; Yenisel Cruz-Almeida; Vonetta Dotson; Natalie Ebner; Philip A Efron; Roger B Fillingim; Thomas C Foster; David M Gundermann; Anna-Maria Joseph; Christy Karabetian; Christiaan Leeuwenburgh; Todd M Manini; Michael Marsiske; Robert T Mankowski; Heather L Mutchie; Michael G Perri; Sanjay Ranka; Parisa Rashidi; Bhanuprasad Sandesara; Philip J Scarpace; Kimberly T Sibille; Laurence M Solberg; Shinichi Someya; Connie Uphold; Stephanie Wohlgemuth; Samuel Shangwu Wu; Marco Pahor Journal: Ageing Res Rev Date: 2015-10-14 Impact factor: 10.895
Authors: Caitlin M Fearing; David W Melton; Xiufen Lei; Heather Hancock; Hanzhou Wang; Zaheer U Sarwar; Laurel Porter; Matthew McHale; Linda M McManus; Paula K Shireman Journal: J Gerontol A Biol Sci Med Sci Date: 2015-08-13 Impact factor: 6.053
Authors: R A Standley; S Z Liu; B Jemiolo; S W Trappe; T A Trappe Journal: Prostaglandins Leukot Essent Fatty Acids Date: 2013-03-13 Impact factor: 4.006
Authors: Todd A Trappe; Robert A Standley; Bozena Jemiolo; Chad C Carroll; Scott W Trappe Journal: Am J Physiol Regul Integr Comp Physiol Date: 2012-12-05 Impact factor: 3.619